Can atherosclerosis be cured?

John T. Wilkins; Samuel S. Gidding; Jennifer G. Robinson

doi:10.1097/MOL.0000000000000644

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Journal article

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Peer reviewed

Can atherosclerosis be cured?

John T. Wilkins, Samuel S. Gidding and Jennifer G. Robinson

Current opinion in lipidology, Vol.30(6), pp.477-484

12/01/2019

DOI: 10.1097/MOL.0000000000000644

PMCID: PMC7375463

PMID: 31592794

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https://www.ncbi.nlm.nih.gov/pmc/articles/7375463View

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Abstract

Purpose of review Determine if evidence supports interventions to prevent development of atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) events and death. Recent findings An extensive body of evidence supports the fundamental causal role of apolipoprotein B lipoproteins in the development of atherosclerosis. Recent epidemiologic studies have shown that LDL-cholesterol (LDL-C) and non-HDL-cholesterol levels in early adults are associated with accelerated subclinical atherosclerosis and an excess of atherosclerotic cardiovascular events later in life. Animal and human data have shown that intensive LDL-C lowering can regress earlier stages of atherosclerosis. Summary The next research priority is evaluating the impact of lowering LDL-C earlier in life to regress early atherosclerosis, followed by trials to demonstrate this approach will eradicate later-life ASCVD events and death. This approach of curing atherosclerosis will likely be the most effective strategy for reducing the huge global burden of atherosclerosis.

Biochemistry & Molecular Biology

Cardiovascular System & Cardiology

Endocrinology & Metabolism

Life Sciences & Biomedicine

Peripheral Vascular Disease

Science & Technology

Details

Title: Subtitle: Can atherosclerosis be cured?
Creators: John T. Wilkins - Northwestern University
Samuel S. Gidding - FH Foundation
Jennifer G. Robinson - Prevent Intervent Ctr, Dept Epidemiol, 145 N Riverside Dr S455 CPHB, Iowa City, IA 52242 USA
Resource Type: Journal article
Publication Details: Current opinion in lipidology, Vol.30(6), pp.477-484
DOI: 10.1097/MOL.0000000000000644
PMID: 31592794
PMCID: PMC7375463
NLM abbreviation: Curr Opin Lipidol
ISSN: 0957-9672
eISSN: 1473-6535
Publisher: Lippincott Williams & Wilkins
Number of pages: 8
Grant note: K23 HL133601-04 / NHLBI K23; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) K23HL133601 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
Language: English
Date published: 12/01/2019
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984363578702771

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