Can fully iterative reconstruction technique enable routine abdominal CT at less than 1 mSv?

Azadeh Tabari; Ramandeep Singh; Ruhani Doda Khera; Yiemeng Hoi; Erin Angel; Mannudeep K. Kalra; Rachna Madan

doi:10.1016/j.ejro.2019.05.001

Back

Can fully iterative reconstruction technique enable routine abdominal CT at less than 1 mSv?

Journal article

Open access

Peer reviewed

Can fully iterative reconstruction technique enable routine abdominal CT at less than 1 mSv?

Azadeh Tabari, Ramandeep Singh, Ruhani Doda Khera, Yiemeng Hoi, Erin Angel, Mannudeep K. Kalra and Rachna Madan

European journal of radiology Open, Vol.6, pp.225-230

01/01/2019

DOI: 10.1016/j.ejro.2019.05.001

PMCID: PMC6603257

PMID: 31304196

Files and links (1)

url

https://doi.org/10.1016/j.ejro.2019.05.001View

Published (Version of record) Open Access

Abstract

We assessed the effect of the forward projected model-based reconstruction technique (FIRST) on lesion detection of routine abdomen CT at <1 mSv. Thirty-seven adult patients gave written informed consent for acquisition of low-dose CT (LDCT) immediately after their clinically-indicated, standard of care dose (SDCT), routine abdomen CT on a 640-slice MDCT (Aquillion One, Canon Medical System). The LDCT series were reconstructed with FIRST (at STD (Standard) and STR (Strong) levels), and SDCT series with filtered back projection (FBP). Two radiologists assessed lesions in LD-FBP and FIRST images followed by SDCT images. Then, SDCT and LDCT were compared for presence of artifacts in a randomized and blinded fashion. Patient demographics, size and radiation dose descriptors (CTDIvol, DLP) were recorded. Descriptive statistics and inter-observer variability were calculated for data analysis. Mean CTDIvol for SDCT and LDCT were 13 ± 4.7 mGy and 2.2 ± 0.8 mGy, respectively. There were 46 true positive lesions detected on SDCT. Radiologists detected 38/46 lesions on LD-FIRST-STD compared to 26/46 lesions on LD-FIRST-STR. The eight lesions (liver and kidney cysts, pancreatic lesions, sub-cm peritoneal lymph node) missed on LD-FIRST-STD were seen in patients with BMI > 25.8 kg/m2. Diagnostic confidence for lesion assessment was optimal in LD-FIRST-STD setting in most patients regardless of their size. The inter-observer agreement (kappa-value) for overall image quality were 0.98 and 0.84 for LD-FIRST-STD and STR levels, respectively. FIRST enabled optimal lesion detection in routine abdomen CT at less than 1 mSv radiation dose in patients with body mass less than ≤25.8 kg/m2.

CT abdomen

Filtered back projection

Forward projected model-based

Iterative reconstruction

Radiation dose

Sub-milli-Sievert

Details

Title: Subtitle: Can fully iterative reconstruction technique enable routine abdominal CT at less than 1 mSv?
Creators: Azadeh Tabari - Massachusetts General Hospital
Ramandeep Singh - Massachusetts General Hospital
Ruhani Doda Khera - Harvard University
Yiemeng Hoi - Varian Medical Systems
Erin Angel - Varian Medical Systems
Mannudeep K. Kalra - Massachusetts General Hospital
Rachna Madan - Brigham and Women's Hospital
Resource Type: Journal article
Publication Details: European journal of radiology Open, Vol.6, pp.225-230
Publisher: Elsevier Ltd
DOI: 10.1016/j.ejro.2019.05.001
PMID: 31304196
PMCID: PMC6603257
ISSN: 2352-0477
eISSN: 2352-0477
Language: English
Date published: 01/01/2019
Academic Unit: Radiology
Record Identifier: 9984697636902771

Metrics

9 Record Views

9 Times Cited - Web of Science

See more details