Journal article
Can phenytoin lower plasma fibrinogen concentrations?
Thrombosis research, Vol.79(3), pp.231-236
1995
DOI: 10.1016/0049-3848(95)00110-D
PMID: 8533119
Abstract
A strong, independent and positive association between plasma fibrinogen concentrations and cardiovascular disease has been established. To determine if phenytoin lowers fibrinogen levels we measured plasma fibrinogen levels in a subset of participants enrolled in arandomized, placebo-controlled, double-blind clinical trial. Participants received placebo or 100 mg, 200 mg, or 300 mg/day of phenytoin for 14 weeks. Fifty-six subjects had post-treatment and 20 had pre- and post-treatment fibrinogen measurements. The phenytoin-treated subjects with post-treatment measurements had a 0.24 g/l (8%) reduction in mean fibrinogen levels compared to placebo (p=0.3). Phenytoin may be capable of producing meaningful reductions in fibrinogen levels.
Details
- Title: Subtitle
- Can phenytoin lower plasma fibrinogen concentrations?
- Creators
- Chris Goerdt - Section of General Internal Medicine, School of Public Health, University of Minnesota USAHanna Bloomfield Rubins - Section of General Internal Medicine, School of Public Health, University of Minnesota USAWilliam Swaim - Department of Internal Medicine, School of Public Health, University of Minnesota USAAaron Folsom - Division of epidemiology, School of Public Health, University of Minnesota USA
- Resource Type
- Journal article
- Publication Details
- Thrombosis research, Vol.79(3), pp.231-236
- DOI
- 10.1016/0049-3848(95)00110-D
- PMID
- 8533119
- NLM abbreviation
- Thromb Res
- ISSN
- 0049-3848
- eISSN
- 1879-2472
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 1995
- Academic Unit
- General Internal Medicine; Internal Medicine
- Record Identifier
- 9984094486502771
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