Logo image
Back
Can postmenopausal hormone replacement improve plasma lipids in women with diabetes? The Atherosclerosis Risk in Communities Study Investigators
Journal article   Open access   Peer reviewed

Can postmenopausal hormone replacement improve plasma lipids in women with diabetes? The Atherosclerosis Risk in Communities Study Investigators

J C Robinson, Aaron R Folsom, Azmi A Nabulsi, Robert Watson, Frederick L Brancati and Jianwen Cai
Diabetes care, Vol.19(5), p.480
05/1996
DOI: 10.2337/diacare.19.5.480
PMID: 8732713
url
https://doi.org/10.2337/diacare.19.5.480View
Published (Version of record) Open Access

Related content

Has comment

Abstract

to evaluate the association of postmenopausal hormone replacement with plasma lipids in diabetic women. Cross-sectional data from a multiracial population study were used to evaluate the relationship of hormone replacement status with plasma lipids in diabetic (n = 694) versus nondiabetic (n = 5,321) postmenopausal women. Although diabetic women who currently used hormone replacement had higher adjusted mean HDL cholesterol levels than those who did not (56.9 vs. 53.6 mg/dl), they had proportionately lower hormone-related increases in HDL, HDL2, and HDL3 cholesterol than did nondiabetic women (HDL cholesterol 64.9 [current users] vs. 55.7 mg/dl [those who never used hormones]). There was a trend toward greater triglyceride values with hormone replacement in diabetic women (156.6 [current users] vs. 125.4 mg/dl [those who never used hormones]) than in nondiabetic women (143.3 [current users] vs. 123.7 mg/dl [those who never used hormones]). LDL cholesterol and apolipoprotein B levels were lower and apolipoprotein A-I levels were higher with hormone replacement, to a similar degree in diabetic and non-diabetic women. Diabetic women appear to have a blunted response to the HDL-raising effects of estrogen and an exaggerated hypertriglyceridemic response. This may result in attenuated cardioprotection from postmenopausal hormone replacement therapy and potentially an increased risk of acute pancreatitis from hypertriglyceridemia. The risks and benefits of postmenopausal hormone replacement need to be carefully weighed in diabetic women.
 United States Diabetes Mellitus - blood Estrogen Replacement Therapy Prevalence Cardiovascular Diseases - prevention & control Cholesterol - blood Humans Middle Aged Alcohol Drinking Intermittent Claudication - epidemiology Lipids - blood Cardiovascular Diseases - epidemiology Postmenopause Angina Pectoris - epidemiology Cholesterol, LDL - blood Female Diabetic Angiopathies - prevention & control Continental Population Groups Cross-Sectional Studies Risk Factors Diabetes Mellitus - physiopathology Triglycerides - blood Cholesterol, HDL - blood Diabetic Angiopathies - epidemiology Cohort Studies Smoking

Details

Metrics

18 Record Views
57 Times Cited - Web of Science
Logo image