Can quality of recovery be enhanced by premedication with midazolam?: A prospective, randomized, double-blind study in females undergoing breast surgery

Myoung Hwa Kim; Min Soo Kim; Jae Hoon Lee; Jae Hi Seo; Jeong-Rim Lee

doi:10.1097/MD.0000000000006107

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Can quality of recovery be enhanced by premedication with midazolam?: A prospective, randomized, double-blind study in females undergoing breast surgery

Journal article

Peer reviewed

Can quality of recovery be enhanced by premedication with midazolam?: A prospective, randomized, double-blind study in females undergoing breast surgery

Myoung Hwa Kim, Min Soo Kim, Jae Hoon Lee, Jae Hi Seo and Jeong-Rim Lee

Medicine (Baltimore), Vol.96(7), pp.e6107-e6107

02/01/2017

DOI: 10.1097/MD.0000000000006107

PMCID: PMC5319519

PMID: 28207530

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Abstract

Preoperative anxiety is known to be related with the postoperative outcomes, although it remains unclear whether pharmacologic anxiolysis preoperatively leads to better postanesthesia recovery. Hence, the purpose of this study was to assess whether midazolam premedication would result in improved Quality of Recovery-40 survey scores, as a postoperative recovery parameter, in female patients undergoing mastectomy. This randomized double-blind study was performed at Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea. Eighty-two females undergoing breast cancer surgery with propofol-remifentanil anesthesia were enrolled and randomized to receive midazolam 0.02 mg kg (group M) or saline (group C). Anesthesia was conducted with total intravenous anesthesia using propofol and remifentanil. On postoperative day 1, the Quality of Recovery-40 survey scores were surveyed. The global Quality of Recovery-40 survey scores on postoperative day 1 did not significantly differ between groups M and C (183 vs 181, P = 0.568). However, the induction time was significantly shorter in group M (3.2 vs 4.5 min, P < 0.001), as was the total intraoperative propofol consumption (705 vs 1004 mg; P = 0.022). Midazolam premedication does not seem to improve the postoperative quality of recovery, though group M showed faster induction and less propofol consumption.

Adult

Aged

Anesthetics, Intravenous - administration & dosage

Anxiety - drug therapy

Breast Neoplasms - psychology

Breast Neoplasms - surgery

Double-Blind Method

Emotions

Female

Health Status

Humans

Hypnotics and Sedatives - administration & dosage

Hypnotics and Sedatives - therapeutic use

Mastectomy - methods

Mental Health

Midazolam - administration & dosage

Midazolam - therapeutic use

Middle Aged

Pain, Postoperative - epidemiology

Piperidines - administration & dosage

Propofol - administration & dosage

Prospective Studies

Quality of Life

Remifentanil

Republic of Korea

Young Adult

Details

Title: Subtitle: Can quality of recovery be enhanced by premedication with midazolam?: A prospective, randomized, double-blind study in females undergoing breast surgery
Creators: Myoung Hwa Kim - Yonsei University
Min Soo Kim
Jae Hoon Lee
Jae Hi Seo
Jeong-Rim Lee
Resource Type: Journal article
Publication Details: Medicine (Baltimore), Vol.96(7), pp.e6107-e6107
DOI: 10.1097/MD.0000000000006107
PMID: 28207530
PMCID: PMC5319519
NLM abbreviation: Medicine (Baltimore)
ISSN: 0025-7974
eISSN: 1536-5964
Language: English
Date published: 02/01/2017
Academic Unit: Anesthesia
Record Identifier: 9984806511802771

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