Journal article
Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting
International journal of molecular sciences, Vol.22(24), p.13408
12/14/2021
DOI: 10.3390/ijms222413408
PMCID: PMC8706283
PMID: 34948209
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related morbidity and mortality in the western world, with limited therapeutic strategies and dismal long-term survival. Cancer-associated fibroblasts (CAFs) are key components of the pancreatic tumor microenvironment, maintaining the extracellular matrix, while also being involved in intricate crosstalk with cancer cells and infiltrating immunocytes. Therefore, they are potential targets for developing therapeutic strategies against PDAC. However, recent studies have demonstrated significant heterogeneity in CAFs with respect to their origins, spatial distribution, and functional phenotypes within the PDAC tumor microenvironment. Therefore, it is imperative to understand and delineate this heterogeneity prior to targeting CAFs for PDAC therapy.
Details
- Title: Subtitle
- Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma: An Update on Heterogeneity and Therapeutic Targeting
- Creators
- Utpreksha Vaish - University of Alabama at BirminghamTejeshwar Jain - University of Alabama at BirminghamAbhi C. Are - University of Alabama at BirminghamVikas Dudeja - University of Alabama at Birmingham
- Resource Type
- Journal article
- Publication Details
- International journal of molecular sciences, Vol.22(24), p.13408
- DOI
- 10.3390/ijms222413408
- PMID
- 34948209
- PMCID
- PMC8706283
- NLM abbreviation
- Int J Mol Sci
- ISSN
- 1661-6596
- eISSN
- 1422-0067
- Publisher
- Mdpi
- Number of pages
- 20
- Language
- English
- Date published
- 12/14/2021
- Academic Unit
- Anatomy and Cell Biology; Surgery
- Record Identifier
- 9985244677802771
Metrics
1 Record Views