Cancer Risk in Persons with Oral Cleft—A Population-based Study of 8,093 Cases

Camilla Bille; Jeanette Falck Winther; Andrea Bautz; Jeffrey C Murray; Jørn Olsen; Kaare Christensen

doi:10.1093/aje/kwi132

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Cancer Risk in Persons with Oral Cleft—A Population-based Study of 8,093 Cases

Journal article

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Cancer Risk in Persons with Oral Cleft—A Population-based Study of 8,093 Cases

Camilla Bille, Jeanette Falck Winther, Andrea Bautz, Jeffrey C Murray, Jørn Olsen and Kaare Christensen

American journal of epidemiology, Vol.161(11), pp.1047-1055

06/01/2005

DOI: 10.1093/aje/kwi132

PMCID: PMC2839121

PMID: 15901625

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Abstract

The authors conducted a nationwide study of the occurrence of cancer among 8,093 Danish oral cleft cases born in 1936 through 1998 and followed in the Danish Cancer Registry from 1968 through 1998, a total of 175,863 person-years, to assess a possible association between cancer and oral clefts. Observed and expected numbers of cancers among oral cleft cases were summarized as the overall and as 52 site-specific standardized incidence ratios. The expected overall number of all cancers was 131, but 140 incident cancers were found, corresponding to a standardized incidence ratio of 1.07 (95% confidence interval (CI): 0.90, 1.26). Analyses of the 52 sites for all oral cleft cases and analyses stratified for three cleft subgroups and the two sexes revealed only a few significant associations: an increased occurrence of breast cancer among females born with cleft lip and/or cleft palate (standardized incidence ratio (SIR) = 1.52, 95% CI: 1.05, 2.14), primary brain cancer among females born with cleft palate (SIR = 3.11, 95% CI: 1.14, 6.78), and primary lung cancer among males born with both cleft lip and cleft palate (SIR = 2.49, 95% CI: 1.00, 5.14). The results do not provide evidence for an increased overall cancer risk for individuals born with oral clefts.

cohort studies

cleft lip

cleft palate

follow-up studies

neoplasms

abnormalities

Details

Title: Subtitle: Cancer Risk in Persons with Oral Cleft—A Population-based Study of 8,093 Cases
Creators: Camilla Bille - Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Jeanette Falck Winther - Institute of Cancer Epidemiology, Copenhagen, Denmark
Andrea Bautz - Institute of Cancer Epidemiology, Copenhagen, Denmark
Jeffrey C Murray - University of Iowa
Jørn Olsen - The Danish Epidemiology Science Centre, University of Aarhus, Aarhus, Denmark
Kaare Christensen - Center for the Prevention of Congenital Malformations, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.161(11), pp.1047-1055
DOI: 10.1093/aje/kwi132
PMID: 15901625
PMCID: PMC2839121
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Language: English
Date published: 06/01/2005
Academic Unit: Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984025367602771

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