Journal article
Cancer and treatment-related symptoms are associated with mobility disability in women with ovarian cancer: A cross-sectional study
Gynecologic oncology, Vol.143(3), pp.578-583
12/2016
DOI: 10.1016/j.ygyno.2016.09.013
PMCID: PMC5116395
PMID: 27653982
Abstract
To examine the prevalence of symptom-related mobility disability and identify specific symptoms and other factors associated with mobility disability among a national sample of ovarian cancer (OC) survivors.
Descriptive, correlational secondary analysis of a National Ovarian Cancer Coalition mailed survey of women with a history of OC (n=713). We used the Symptom Representation Questionnaire (SRQ), the MD Anderson Symptom Inventory (MDASI) Interference Scale, and medical and demographic information to determine prevalence of symptom-related mobility disability. We constructed a multiple linear regression model to determine the relative contributions of specific symptoms and other factors to mobility disability.
A majority of the sample (60.0%) reported symptom-related mobility disability. Independent predictors included: > one comorbidity (β=0.112, p=0.001), active OC (β=0.111, p=0.037), abdominal bloating (β=0.097, p=0.006), fatigue (β=0.314, p<0.001), lack of appetite (β=0.072, p=0.045), numbness/tingling (β=0.134, p<0.001), and pain (β=0.194, p<0.001). The model explained 41.5% of the variance in symptom-related mobility disability (R2=0.415). Unexpectedly, age (β=−0.028, p=0.412) and current chemotherapy (β=0.107, p=0.118) were not significant predictors.
Symptom-related mobility disability is common among women with OC and is associated with medical comorbidities, abdominal bloating, fatigue, lack of appetite, numbness/tingling, and pain. Longitudinal research should clarify the relationship of these symptoms to mobility disability and determine whether effective symptom management minimizes disability.
•Mobility disability is endorsed by over half of women with ovarian cancer.•Poor appetite, bloating, fatigue, pain, numbness correlate with disability.•Clinicians should assess for mobility disability in women with ovarian cancer.
Details
- Title: Subtitle
- Cancer and treatment-related symptoms are associated with mobility disability in women with ovarian cancer: A cross-sectional study
- Creators
- Grace Campbell - University of Pittsburgh School of Nursing, 336 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, United StatesTeresa Hagan - Massachusetts General Hospital, Harvard Medical School, Yawkey Center, 55 Fruit Street, Boston, MA 02114, United StatesStephanie Gilbertson-White - University of Iowa College of Nursing, 50 Newton Road, 444 College of Nursing Building, Iowa City, IA 52242, United StatesMartin Houze - University of Pittsburgh School of Nursing, 336 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, United StatesHeidi Donovan - University of Pittsburgh School of Nursing, 336 Victoria Building, 3500 Victoria Street, Pittsburgh, PA 15261, United States
- Resource Type
- Journal article
- Publication Details
- Gynecologic oncology, Vol.143(3), pp.578-583
- DOI
- 10.1016/j.ygyno.2016.09.013
- PMID
- 27653982
- PMCID
- PMC5116395
- NLM abbreviation
- Gynecol Oncol
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 12/2016
- Academic Unit
- Nursing; Internal Medicine
- Record Identifier
- 9984064161402771
Metrics
31 Record Views