Cancer-associated retinopathy

S M Goldstein; N A Syed; A H Milam; A M Maguire; T J Lawton; C W Nichols

doi:10.1001/archopht.117.12.1641

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Journal article

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Peer reviewed

Cancer-associated retinopathy

S M Goldstein, N A Syed, A H Milam, A M Maguire, T J Lawton and C W Nichols

Archives of ophthalmology (1960), Vol.117(12), pp.1641-1645

12/1999

DOI: 10.1001/archopht.117.12.1641

PMID: 10604671

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Abstract

Patients with systemic cancer may have a variety of ocular complaints. Most commonly these are metastases or adverse effects of therapy. Paraneoplastic syndromes, like cancer-associated retinopathy, rarely cause ophthalmic symptoms. We describe a patient with a malignant mixed mullerian tumor and cancer-associated retinopathy who had circulating serum antibodies to recoverin and cells positive for recoverin in the tumor. We discuss the typical clinical symptoms as well as the pathophysiology of this uncommon disorder.

Retinal Diseases - immunology

Uterine Neoplasms - pathology

Humans

Middle Aged

Recoverin

Visual Fields

Antineoplastic Agents, Hormonal - therapeutic use

Antigens, Neoplasm - blood

Fatal Outcome

Retinal Diseases - pathology

Female

Uterine Neoplasms - radiotherapy

Hippocalcin

Paraneoplastic Syndromes - immunology

Calcium-Binding Proteins - blood

Fluorescent Antibody Technique, Indirect

Electroretinography

Mixed Tumor, Mullerian - radiotherapy

Nerve Tissue Proteins

Visual Acuity

Mixed Tumor, Mullerian - pathology

Biomarkers, Tumor - blood

Lipoproteins

Paraneoplastic Syndromes - pathology

Paraneoplastic Syndromes - drug therapy

Retinal Diseases - drug therapy

Eye Proteins

Fundus Oculi

Mixed Tumor, Mullerian - immunology

Prednisone - therapeutic use

Uterine Neoplasms - immunology

Details

Title: Subtitle: Cancer-associated retinopathy
Creators: S M Goldstein - Department of Ophthalmology, Scheie Eye Institute and the Hospital of the University of Pennsylvania, Philadelphia, USA
N A Syed
A H Milam
A M Maguire
T J Lawton
C W Nichols
Resource Type: Journal article
Publication Details: Archives of ophthalmology (1960), Vol.117(12), pp.1641-1645
DOI: 10.1001/archopht.117.12.1641
PMID: 10604671
NLM abbreviation: Arch Ophthalmol
ISSN: 0003-9950
eISSN: 1538-3601
Publisher: American Medical Association; United States
Language: English
Date published: 12/1999
Academic Unit: Pathology; Ophthalmology and Visual Sciences
Record Identifier: 9983980294002771

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