Journal article
Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling
Oncogene, Vol.39(14), pp.2877-2889
04/2020
DOI: 10.1038/s41388-020-1203-x
PMCID: PMC7127950
PMID: 32042113
Abstract
Aiming to identify immune molecules with a novel function in cancer pathogenesis, we found the cluster of differentiation 177 (CD177), a known neutrophil antigen, to be positively correlated with relapse-free, metastasis-free, or overall survival in breast cancer. In addition, CD177 expression is correlated with good prognosis in several other solid cancers including prostate, cervical, and lung. Focusing on breast cancer, we found that CD177 is expressed in normal breast epithelial cells and is significantly reduced in invasive cancers. Loss of CD177 leads to hyperproliferative mammary epithelium and contributes to breast cancer pathogenesis. Mechanistically, we found that CD177-deficiency is associated with an increase in β-catenin signaling. Here we identified CD177 as a novel regulator of mammary epithelial proliferation and breast cancer pathogenesis likely via the modulation of Wnt/β-catenin signaling pathway, a key signaling pathway involved in multiple cancer types.
Details
- Title: Subtitle
- Cancer cell-intrinsic function of CD177 in attenuating β-catenin signaling
- Creators
- Ryan Kolb - University of FloridaNicholas Borcherding - University of IowaQing Xie - Xinxiang Medical UniversityQi Liu - University of IowaChristopher Stipp - University of IowaKatherine N Gibson-Corley - University of IowaChen Zhao - University of IowaYuewan Luo - University of IowaMyung-Chul Kim - University of IowaHank H Qi - University of IowaLinna Wang - Purdue University West LafayetteAndrew Bellizzi - University of IowaYinan Zhang - Nankai UniversitySonia Sugg - University of IowaWei Li - University of IowaRonald J Weigel - University of IowaPaige N Kluz - University of IowaWeizhou Zhang - University of FloridaAndy W Tao - Purdue University West LafayetteDaohong Zhou - University of FloridaXian Shen - Wenzhou Medical University
- Resource Type
- Journal article
- Publication Details
- Oncogene, Vol.39(14), pp.2877-2889
- DOI
- 10.1038/s41388-020-1203-x
- PMID
- 32042113
- PMCID
- PMC7127950
- NLM abbreviation
- Oncogene
- ISSN
- 0950-9232
- eISSN
- 1476-5594
- Grant note
- R00 CA158055 / NCI NIH HHS R01 CA203834 / NCI NIH HHS T32 HL007344 / NHLBI NIH HHS T32 GM007337 / NIGMS NIH HHS F30 CA206255 / NCI NIH HHS R01 CA200673 / NCI NIH HHS P30 CA086862 / NCI NIH HHS
- Language
- English
- Date published
- 04/2020
- Academic Unit
- Dermatology; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Pathology; Orthopedics and Rehabilitation; Surgery; Biology; Radiation Oncology; Biochemistry and Molecular Biology; Ophthalmology and Visual Sciences
- Record Identifier
- 9984183986202771
Metrics
28 Record Views