Journal article
Cancer genetics and breast cancer
Best practice & research. Clinical obstetrics & gynaecology, Vol.82, pp.3-11
06/2022
DOI: 10.1016/j.bpobgyn.2022.01.007
PMID: 35272929
Abstract
The risk of developing breast cancer is multifactorial and, at times, modifiable. However, the risk imposed by family history and hereditary pathogenic variants in a person's genetic code is, at present, an important fixed variable. Therefore, it is imperative to identify patients at risk for hereditary breast cancer and to understand the current evidence-based approach to the management of that risk. This chapter focuses on how genes play a role in breast cancer risk, why certain genes are commonly involved in hereditary breast cancer, and what are the specific genes and genetic syndromes that put patients at risk for breast cancer. Hereditary cancer susceptibility syndromes, including Hereditary Breast and Ovarian Cancer Syndrome (HBOC – BRCA1/2), Cowden Syndrome (CS – PTEN), Li-Fraumeni Syndrome (LFS – TP53), Peutz-Jegher Syndrome (PJS – STK11), Neurofibromatosis Type 1 (NF1), and Diffuse Hereditary Gastric Cancer Syndrome (CDH1) will be discussed along with individual genes not associated with a particular syndrome (ATM, BARD1, CHEK2, and PALB2).
•Hereditary breast cancer can be caused by several genes other than BRCA1 or BRCA2.•High-risk breast screening includes annual 3D mammogram (if available) along with annual breast MRI with contrast.•Guidelines for the management of hereditary breast cancer are frequently updated.
Details
- Title: Subtitle
- Cancer genetics and breast cancer
- Creators
- Kathryn J. Huber-Keener - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- Best practice & research. Clinical obstetrics & gynaecology, Vol.82, pp.3-11
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.bpobgyn.2022.01.007
- PMID
- 35272929
- ISSN
- 1521-6934
- eISSN
- 1532-1932
- Language
- English
- Date published
- 06/2022
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318221702771
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