Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon

Laura E Beane Freeman; Matthew R Bonner; Aaron Blair; Jane A Hoppin; Dale P Sandler; Jay H Lubin; Mustafa Dosemeci; Charles F Lynch; Charles Knott; Michael C R Alavanja

doi:10.1093/aje/kwi321

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Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon

Journal article

Open access

Peer reviewed

Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon

Laura E Beane Freeman, Matthew R Bonner, Aaron Blair, Jane A Hoppin, Dale P Sandler, Jay H Lubin, Mustafa Dosemeci, Charles F Lynch, Charles Knott and Michael C R Alavanja

American journal of epidemiology, Vol.162(11), pp.1070-1079

12/01/2005

DOI: 10.1093/aje/kwi321

PMID: 16236997

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Abstract

Little is known about the potential carcinogenicity associated with routine application of diazinon, a common organophosphate insecticide. The authors explored a possible association of diazinon exposure with cancer risk in the Agricultural Health Study, a prospective cohort of licensed pesticide applicators in Iowa and North Carolina enrolled in 1993-1997. A total of 23,106 male applicators provided information in a self-administered questionnaire. Among 4,961 applicators who reported using diazinon, 301 incident cancer cases were diagnosed during the follow-up period ending December 2002 compared with 968 cases among 18,145 participants who reported no use. Poisson regression was used to calculate rate ratios and 95% confidence intervals. Two quantitative exposure metrics were used: lifetime exposure days and intensity-weighted lifetime exposure days, a measure that incorporates probability of pesticide exposure with lifetime pesticide application frequency. When lifetime exposure days were used, increased risks for the highest tertile of exposure and significant tests for trend for lung cancer and leukemia were observed. No other cancer site showed an association with diazinon for the highest tertile of exposure. Because these results were based on small numbers, additional analyses are necessary as more cases accrue to clarify whether diazinon is associated with cancer risk in humans.

Confidence Intervals

Prospective Studies

Comorbidity

Diazinon - toxicity

Occupational Exposure - adverse effects

Humans

Middle Aged

Risk Factors

Agricultural Workers' Diseases - epidemiology

Male

Models, Statistical

Incidence

Neoplasms - chemically induced

Smoking - epidemiology

Aged, 80 and over

Adult

Iowa - epidemiology

Aged

Insecticides - toxicity

North Carolina - epidemiology

Neoplasms - epidemiology

Occupational Exposure - statistics & numerical data

Agricultural Workers' Diseases - chemically induced

Cohort Studies

Details

Title: Subtitle: Cancer incidence among male pesticide applicators in the Agricultural Health Study cohort exposed to diazinon
Creators: Laura E Beane Freeman - Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20892, USA
Matthew R Bonner
Aaron Blair
Jane A Hoppin
Dale P Sandler
Jay H Lubin
Mustafa Dosemeci
Charles F Lynch
Charles Knott
Michael C R Alavanja
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.162(11), pp.1070-1079
DOI: 10.1093/aje/kwi321
PMID: 16236997
NLM abbreviation: Am J Epidemiol
ISSN: 0002-9262
eISSN: 1476-6256
Publisher: United States
Grant note: Intramural NIH HHS
Language: English
Date published: 12/01/2005
Academic Unit: Epidemiology
Record Identifier: 9983996088502771

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