Journal article
Cancer incidence and associations with known risk and protective factors: the Alaska EARTH study
Cancer causes & control, Vol.30(10), pp.1067-1074
10/2019
DOI: 10.1007/s10552-019-01216-9
PMCID: PMC6736715
PMID: 31428891
Abstract
Cancer is the leading cause of mortality among Alaska Native (AN) people. The Alaska Education and Research Towards Health (EARTH) cohort was established to examine risk and protective factors for chronic diseases, including cancer, among AN people. Here, we describe the cancer experience of the Alaska EARTH cohort in relation to statewide- and region-specific tumor registry data, and assess associations with key cancer risk factors.
AN participants were recruited into the Alaska EARTH cohort during 2004-2006. Data collected included patient demographic, anthropometric, medical and family history, and lifestyle information. This study linked the Alaska EARTH data with cancer diagnoses recorded by the Alaska Native Tumor Registry (ANTR) through 12/31/15. We compared EARTH incidence to ANTR statewide incidence. We examined independent associations of smoking status, diet, BMI, and physical activity with incident all-site cancers using multivariable-adjusted Cox proportional hazards models.
Between study enrollment and 2015, 171 of 3,712 (4.7%) Alaska EARTH study participants were diagnosed with cancer. The leading cancers among Alaska EARTH participants were female breast, lung, and colorectal cancer, which reflected those observed among AN people statewide. Incidence (95% CI) of cancer (all sites) among Alaska EARTH participants was 629.7 (510.9-748.6) per 100,000 person-years; this was comparable to statewide rates [680.5 (660.0-701.5) per 100,000 population]. We observed lower risk of all-sites cancer incidence among never smokers.
Cancer incidence in the Alaska EARTH cohort was similar to incidence observed statewide. Risk and protective factors for leading cancers among AN people mirror those observed among other populations.
Details
- Title: Subtitle
- Cancer incidence and associations with known risk and protective factors: the Alaska EARTH study
- Creators
- Sarah H Nash - Alaska Native Epidemiology Center, Alaska Native Tumor Registry, Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, USA. shnash@anthc.orgGretchen Day - Clinical and Research Services, Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, USAGarrett Zimpelman - Alaska Native Epidemiology Center, Alaska Native Tumor Registry, Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, USAVanessa Y Hiratsuka - Research Department, Southcentral Foundation, Anchorage, AK, USAKathryn R Koller - Clinical and Research Services, Community Health Services, Alaska Native Tribal Health Consortium, Anchorage, AK, USA
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.30(10), pp.1067-1074
- DOI
- 10.1007/s10552-019-01216-9
- PMID
- 31428891
- PMCID
- PMC6736715
- NLM abbreviation
- Cancer Causes Control
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Grant note
- NCI contract number HHSN26120130010I, Task Order HHSN26100005 / Division of Cancer Prevention, National Cancer Institute (US) CA88958 / National Cancer Institute (US) S06 GM123545 / NIGMS NIH HHS U261IHS0084 / National Institute of General Medical Sciences (US) 1S06GM123545 / National Institute for General Medical Sciences (US) CA96095 / NCI NIH HHS
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Epidemiology; Center for Social Science Innovation
- Record Identifier
- 9984214670202771
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