Cancer incidence in the Agricultural Health Study after 20 years of follow-up

Catherine C Lerro; Stella Koutros; Gabriella Andreotti; Dale P Sandler; Charles F Lynch; Lydia M Louis; Aaron Blair; Christine G Parks; Srishti Shrestha; Jay H Lubin; Paul S Albert; Jonathan N Hofmann; Laura E Beane Freeman

doi:10.1007/s10552-019-01140-y

Back

Cancer incidence in the Agricultural Health Study after 20 years of follow-up

Journal article

Open access

Peer reviewed

Cancer incidence in the Agricultural Health Study after 20 years of follow-up

Catherine C Lerro, Stella Koutros, Gabriella Andreotti, Dale P Sandler, Charles F Lynch, Lydia M Louis, Aaron Blair, Christine G Parks, Srishti Shrestha, Jay H Lubin, …

Cancer causes & control, Vol.30(4), pp.311-322

04/2019

DOI: 10.1007/s10552-019-01140-y

PMCID: PMC6459699

PMID: 30805813

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/6459699View

Open Access

Abstract

To evaluate cancer incidence in the Agricultural Health Study (AHS), a cohort of private pesticide applicators, their spouses, and commercial applicators, based on 12,420 cancers, adding 5,989 cancers, and 9 years of follow-up since last evaluation. We calculated age, year, sex, and race-adjusted standardized incidence ratios (SIR) and 95% confidence intervals (CI) for cancer sites in the AHS relative to the general population. Overall AHS cancer incidence was lower than the general population (SIR = 0.91, CI 0.89-0.93; SIR = 0.89, CI 0.86-0.92; SIR = 0.83, CI 0.76-0.92), with notable deficits across applicators and spouses for oral cavity, pancreas, and lung cancers. Cancer excesses included prostate cancer, lip cancer, certain B-cell lymphomas (e.g., multiple myeloma), acute myeloid leukemia (AML), thyroid cancer, testicular cancer, and peritoneal cancer. The lung cancer deficit was strongest among applicators reporting potential exposure to endotoxin at study enrollment (tasks such as raising animals and handling stored grain). Although an overall deficit in cancer was observed, there were notable exceptions, including newly observed excesses for AML, thyroid, testicular, and peritoneal cancers. Furthermore, endotoxin exposure may, in part, account for observed lung cancer incidence deficits. Cancer incidence patterns in the AHS suggest farm exposures' relevance to cancer etiology.

Pesticides

Spouses - statistics & numerical data

Follow-Up Studies

Occupational Exposure - adverse effects

Humans

Middle Aged

Female

Male

Aged

Neoplasms - epidemiology

Cohort Studies

Incidence

Details

Title: Subtitle: Cancer incidence in the Agricultural Health Study after 20 years of follow-up
Creators: Catherine C Lerro - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA. catherine.lerro@nih.gov
Stella Koutros - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Gabriella Andreotti - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Dale P Sandler - National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA
Charles F Lynch - Department of Epidemiology, University of Iowa, 145 N. Riverside Drive, Iowa City, IA, 52242, USA
Lydia M Louis - National Cancer Institute
Aaron Blair - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Christine G Parks - National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC, 27709, USA
Srishti Shrestha - National Institute of Environmental Health Sciences
Jay H Lubin - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Paul S Albert - Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Jonathan N Hofmann - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Laura E Beane Freeman - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6E116, 9609 Medical Center Drive, Rockville, MD, 20850, USA
Resource Type: Journal article
Publication Details: Cancer causes & control, Vol.30(4), pp.311-322
DOI: 10.1007/s10552-019-01140-y
PMID: 30805813
PMCID: PMC6459699
NLM abbreviation: Cancer Causes Control
ISSN: 1573-7225
eISSN: 1573-7225
Publisher: Netherlands
Grant note: P30 ES005605 / NIEHS NIH HHS Z01-CP010119 / NCI NIH HHS Z01 ES049030 / Intramural NIH HHS Z99 CA999999 / Intramural NIH HHS Z01 CP010119 / Intramural NIH HHS Z01-ES049030 / NIEHS NIH HHS P30 CA086862 / NCI NIH HHS
Language: English
Date published: 04/2019
Academic Unit: Epidemiology
Record Identifier: 9983996195002771

Metrics

38 Record Views

54 Times Cited - Web of Science

See more details