Cancer induces inflammation and depressive-like behavior in the mouse: Modulation by social housing

Donald M Lamkin; Susan K Lutgendorf; David Lubaroff; Anil K Sood; Terry G Beltz; Alan Kim Johnson

doi:10.1016/j.bbi.2010.12.010

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Cancer induces inflammation and depressive-like behavior in the mouse: Modulation by social housing

Journal article

Peer reviewed

Cancer induces inflammation and depressive-like behavior in the mouse: Modulation by social housing

Donald M Lamkin, Susan K Lutgendorf, David Lubaroff, Anil K Sood, Terry G Beltz and Alan Kim Johnson

Brain, behavior, and immunity, Vol.25(3), pp.555-564

03/2011

DOI: 10.1016/j.bbi.2010.12.010

PMCID: PMC3039064

PMID: 21182930

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Abstract

Considerable data demonstrate a high prevalence of depressive symptoms in cancer patients. This study introduces an experimental model to examine the effect of tumor on depressive-like behavior. Female C57BL/6 mice were injected i.p. with syngeneic ID8 ovarian carcinoma. Experiment 1 measured sucrose intake before and after tumor incubation to assess the effect of tumor on anhedonic depressive-like behavior. Experiment 2 examined effects of tumor and social housing on anhedonia and a second depressive-like behavior, tail suspension test (TST) immobility. Systemic proinflammatory and antiinflammatory cytokines were measured following each experiment. Additional behaviors assessed the specificity of tumor’s effect on depressive-like behavior. Tumor caused a reduction in sucrose intake relative to baseline and control levels (P<.05). Moreover, individually-housed tumor-bearing mice exhibited a lower sucrose preference than group-housed tumor-bearing or control mice in either housing condition (P<.05). Although tumor-bearing mice exhibited less locomotion than controls (P<.001), there was no significant effect of tumor on TST immobility. Tumor caused higher levels of systemic proinflammatory and antiinflammatory cytokines and smaller body weight (P<.05), but appetite and motor capacity were not significantly affected. Statistical mediation analysis showed that circulating interleukin-6 partially mediated the effect between tumor and home cage locomotion (P<.01) but not between tumor and sucrose intake. It is concluded that tumor elicits anhedonic depressive-like behavior in a murine model of ovarian cancer. This may have important implications for etiology of depression in the clinical cancer setting.

Inflammation

Cytokines

Ovarian Cancer

Locomotion

Anhedonia

Tail suspension test

Details

Title: Subtitle: Cancer induces inflammation and depressive-like behavior in the mouse: Modulation by social housing
Creators: Donald M Lamkin - Department of Psychology, University of Iowa, IA, USA
Susan K Lutgendorf - Department of Psychology, University of Iowa, IA, USA
David Lubaroff - Department of Urology, University of Iowa, IA, USA
Anil K Sood - Department of Gynecologic Oncology, M.D. Anderson Cancer Center, University of Texas, TX, USA
Terry G Beltz - Department of Psychology, University of Iowa, IA, USA
Alan Kim Johnson - Department of Psychology, University of Iowa, IA, USA
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.25(3), pp.555-564
DOI: 10.1016/j.bbi.2010.12.010
PMID: 21182930
PMCID: PMC3039064
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Elsevier Inc
Grant note: name: NIH, award: R03 CA132573-01A1, R01 CA104825, R01 CA140933, P01 HL-14388, R01 DK-66086, R01 MH80241, T32-MH19925
Language: English
Date published: 03/2011
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Neuroscience and Pharmacology; Urology; Health, Sport, and Human Physiology
Record Identifier: 9984002592202771

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