Cancer risk among lung transplant recipients with cystic fibrosis

Aliza K Fink; Elizabeth L Yanik; Bruce C Marshall; Michael Wilschanski; Charles F Lynch; April A Austin; Glenn Copeland; Mahboobeh Safaeian; Eric A Engels

doi:10.1016/j.jcf.2016.07.011

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Cancer risk among lung transplant recipients with cystic fibrosis

Journal article

Open access

Peer reviewed

Cancer risk among lung transplant recipients with cystic fibrosis

Aliza K Fink, Elizabeth L Yanik, Bruce C Marshall, Michael Wilschanski, Charles F Lynch, April A Austin, Glenn Copeland, Mahboobeh Safaeian and Eric A Engels

Journal of cystic fibrosis, Vol.16(1), pp.91-97

01/2017

DOI: 10.1016/j.jcf.2016.07.011

PMID: 27539828

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Abstract

Previous studies demonstrated increased digestive tract cancers among individuals with cystic fibrosis (CF), particularly among lung transplant recipients. We describe cancer incidence among CF and non-CF lung recipients. We used data from the US transplant registry and 16 cancer registries. Standardized incidence ratios (SIRs) compared cancer incidence to the general population, and competing risk methods were used for the cumulative incidence of colorectal cancer. We evaluated 10,179 lung recipients (1681 with CF). Risk was more strongly increased in CF recipients than non-CF recipients for overall cancer (SIR 9.9 vs. 2.7) and multiple cancers including colorectal cancer (24.2 vs. 1.7), esophageal cancer (56.3 vs. 1.3), and non-Hodgkin lymphoma (61.8 vs. 9.4). At five years post-transplant, colorectal cancer was diagnosed in 0.3% of CF recipients aged <50 at transplant and 6.4% aged ≥50. CF recipients have increased risk for colorectal cancer, suggesting a need for enhanced screening.

Cancer

Transplant

Details

Title: Subtitle: Cancer risk among lung transplant recipients with cystic fibrosis
Creators: Aliza K Fink - Cystic Fibrosis Foundation, Bethesda, MD, USA
Elizabeth L Yanik - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Bruce C Marshall - Cystic Fibrosis Foundation, Bethesda, MD, USA
Michael Wilschanski - Department of Pediatric Gastroenterology, Hadassah Hebrew University Medical Center, Jerusalem, Israel
Charles F Lynch - Department of Epidemiology, The University of Iowa, Iowa City, IA, USA
April A Austin - New York State Cancer Registry, New York State Department of Health, Albany, NY, USA
Glenn Copeland - Michigan Cancer Surveillance Program, Michigan Department of Health and Human Services, Lansing, MI, USA
Mahboobeh Safaeian - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Eric A Engels - Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
Resource Type: Journal article
Publication Details: Journal of cystic fibrosis, Vol.16(1), pp.91-97
DOI: 10.1016/j.jcf.2016.07.011
PMID: 27539828
NLM abbreviation: J Cyst Fibros
ISSN: 1569-1993
eISSN: 1873-5010
Publisher: Elsevier B.V
Grant note: name: Intramural Research Program of the National Cancer Institute
Language: English
Date published: 01/2017
Academic Unit: Epidemiology
Record Identifier: 9983996187002771

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