Journal article
Cancer stem cells in the mechanism of metal carcinogenesis
Journal of environmental pathology, toxicology and oncology, Vol.31(3), pp.245-263
2012
DOI: 10.1615/JEnvironPatholToxicolOncol.v31.i3.60
PMID: 23339699
Abstract
Environmental metal carcinogenesis is a major public health concern. The mechanism underlying metal-induced carcinogenesis remains unclear. The concept of cancer stem cell recently has drawn considerable attention. Various studies indicate that the generation of cancer stem cells might contribute to the overall mechanism of development of metal-induced cancer. It is believed that oxidative stress and abnormal signaling caused by metals lead to the enrichment of cancer stem cells and eventually initiate cancer. In addition, metal-induced angiogenesis may also contribute to the generation of cancer stem cells. Studies using animal models further suggest that metals could induce the production of cancer stem cells and thus cause the development of cancer. This review summarizes recent studies of oxidative stress and cancer stem cells in relation to the mechanism of metal carcinogenesis.
Details
- Title: Subtitle
- Cancer stem cells in the mechanism of metal carcinogenesis
- Creators
- Lei Wang - University of KentuckyFei Chen - Eugene Applebaum College of Pharmacy and Health SciencesZhuo Zhang - University of KentuckyGang Chen - University of KentuckyJia Luo - University of KentuckyXianglin Shi - University of Kentucky
- Resource Type
- Journal article
- Publication Details
- Journal of environmental pathology, toxicology and oncology, Vol.31(3), pp.245-263
- DOI
- 10.1615/JEnvironPatholToxicolOncol.v31.i3.60
- PMID
- 23339699
- ISSN
- 0731-8898
- eISSN
- 2162-6537
- Grant note
- R01ES015518 / NIEHS NIH HHS R01 ES020870 / NIEHS NIH HHS R01CA116697 / NCI NIH HHS R01ES015375 / NIEHS NIH HHS
- Language
- English
- Date published
- 2012
- Academic Unit
- Pathology
- Record Identifier
- 9984201253102771
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