Journal article
Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women
The Journal of Maternal-Fetal & Neonatal Medicine, Vol.28(7), pp.804-811
05/03/2015
DOI: 10.3109/14767058.2014.932768
PMCID: PMC4289663
PMID: 25014319
Abstract
Objective: Prenatal smoking, alcohol use, and obesity have significant effects on maternal and fetal health. However, not much is known about the genetic contributions to these risk factors among pregnant women. We evaluate the associations between several candidate genes and smoking, alcohol use, pre-pregnancy body weight, and weight gain during pregnancy in a sample of pregnant women.
Methods: The study analyzes a sample of about 1900 mothers from the Danish National Birth Cohort. We test the association between 1450 SNPs in/near 117 genes/loci and various risk factor measures.
Results: Only a few SNPs in FTO were significantly associated with pre-pregnancy obesity and body mass index (4 and 2 SNPs, respectively) after SNP-level correction for multiple testing. A few loci were significantly related to various smoking measures (any smoking, quitting and cigarette number) with gene/locus-level correction for multiple testing, but not after SNP-level correction. Similarly, some loci were significant for the alcohol measures at the gene/locus-level but not at SNP-level correction.
Conclusion: The study suggests that the majority of the evaluated candidate genes may not play an important role in influencing these risk factors among pregnant women, highlighting the importance of other genetic factors and non-genetic contributors to their etiology.
Details
- Title: Subtitle
- Candidate gene study for smoking, alcohol use, and body weight in a sample of pregnant women
- Creators
- George L Wehby - Department of Health Management and PolicyKaitlin N Prater - Department of Health Management and PolicyKelli K Ryckman - Department of Epidemiology, College of Public Health, University of IowaColleen Kummet - Department of Epidemiology, College of Public Health, University of IowaJeffrey C Murray - Department of Pediatrics, College of Medicine, University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of Maternal-Fetal & Neonatal Medicine, Vol.28(7), pp.804-811
- DOI
- 10.3109/14767058.2014.932768
- PMID
- 25014319
- PMCID
- PMC4289663
- NLM abbreviation
- J Matern Fetal Neonatal Med
- ISSN
- 1476-7058
- eISSN
- 1476-4954
- Publisher
- Informa Healthcare
- Language
- English
- Date published
- 05/03/2015
- Academic Unit
- Preventive and Community Dentistry; Anatomy and Cell Biology; Health Management and Policy; International Programs; Stead Family Department of Pediatrics; Epidemiology; Economics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Public Policy Center (Archive); Dental Research
- Record Identifier
- 9983995179802771
Metrics
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