Journal article
Candidemia surveillance in Iowa: emergence of echinocandin resistance
Diagnostic microbiology and infectious disease, Vol.79(2), pp.205-208
06/2014
DOI: 10.1016/j.diagmicrobio.2014.02.016
PMID: 24666704
Abstract
We performed prospective surveillance for candidemia at 14 Iowa hospitals in 2011–2012. A total of 163 episodes were analyzed. Candida albicans (n = 69 [42%]) and Candida glabrata (n = 58 [36%]) were the most common species. Antifungal resistance was uncommon; 9% of C. glabrata were fluconazole resistant, and 5% (3 isolates) were intermediate or resistant to 1 or more of the echinocandins. Molecular analyses of the fks1 and fks2 hotspots of the C. glabrata revealed no mutations except in 2 of these 3 isolates (L628R and S629P in fks1). Compared with previous surveillance performed in 1998–2001, there was a decrease in proportion of candidemia due to C. albicans (58 to 42%) and an increased proportion due to C. glabrata (20 to 36%). Further emergence of echinocandin resistance among the increasingly common species C. glabrata would complicate the management of this life-threatening infection.
Details
- Title: Subtitle
- Candidemia surveillance in Iowa: emergence of echinocandin resistance
- Creators
- Eiyu Matsumoto - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52246Linda Boyken - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52246Shailesh Tendolkar - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52246Jennifer McDanel - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52246Mariana Castanheira - JMI Laboratories, North Liberty, IAMichael Pfaller - Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA 52246Daniel Diekema - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA 52246
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.79(2), pp.205-208
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.diagmicrobio.2014.02.016
- PMID
- 24666704
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Internal Medicine
- Record Identifier
- 9983986266402771
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