Cannabinoid agonist administration within the cerebellar cortex impairs motor learning

Adam B Steinmetz; John H Freeman

doi:10.1016/j.nlm.2018.06.015

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Cannabinoid agonist administration within the cerebellar cortex impairs motor learning

Journal article

Peer reviewed

Cannabinoid agonist administration within the cerebellar cortex impairs motor learning

Adam B Steinmetz and John H Freeman

Neurobiology of learning and memory, Vol.170, pp.106896-106896

04/2020

DOI: 10.1016/j.nlm.2018.06.015

PMCID: PMC6311437

PMID: 29964164

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https://www.ncbi.nlm.nih.gov/pmc/articles/6311437View

Open Access

Abstract

Systemic administration of cannabinoid agonists impairs cerebellum-dependent motor learning. The cannabinoid-induced impairment of motor learning has been hypothesized to be due to disruption of Purkinje cell plasticity within the cerebellar cortex. In the current study, we tested this hypothesis in rats with localized microinfusions of cannabinoid agonists and antagonists into the cerebellar cortex during eyeblink conditioning, a type of cerebellum-dependent motor learning. Infusions of the cannabinoid agonists WIN55,212-2 or ACEA directly into the eyeblink conditioning microzone of the cerebellar cortex severely impaired acquisition of eyeblink conditioning, whereas the CB1R antagonist SR141716A did not produce a significant impairment. Infusions of WIN55,212-2 outside of the eyeblink conditioning microzone did not impair motor learning, establishing anatomical specificity for the agonist effects. The motor learning impairment caused by WIN55,212-2 and ACEA was rescued by SR141716A, indicating that the learning deficit was produced through CB1Rs. The current findings demonstrate that the effects of cannabinoid receptor agonists on motor learning are localized to CB1Rs within a discrete microzone of the cerebellar cortex.

Conditioning, Eyelid - physiology

Animals

Rats, Long-Evans

Cerebellum - drug effects

Male

Cerebellum - physiology

Cannabinoid Receptor Agonists - administration & dosage

Receptor, Cannabinoid, CB1 - physiology

Conditioning, Eyelid - drug effects

Details

Title: Subtitle: Cannabinoid agonist administration within the cerebellar cortex impairs motor learning
Creators: Adam B Steinmetz - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA 52242, USA
John H Freeman - Department of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA 52242, USA. Electronic address: john-freeman@uiowa.edu
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.170, pp.106896-106896
DOI: 10.1016/j.nlm.2018.06.015
PMID: 29964164
PMCID: PMC6311437
NLM abbreviation: Neurobiol Learn Mem
ISSN: 1074-7427
eISSN: 1095-9564
Publisher: United States
Grant note: R01 MH080005 / NIMH NIH HHS R01 NS088567 / NINDS NIH HHS
Language: English
Date published: 04/2020
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065860902771

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6 Times Cited - Web of Science