Cannabinoid modulation of memory consolidation within the cerebellum

Adam B Steinmetz; John H Freeman

doi:10.1016/j.nlm.2016.11.002

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Cannabinoid modulation of memory consolidation within the cerebellum

Journal article

Peer reviewed

Cannabinoid modulation of memory consolidation within the cerebellum

Adam B Steinmetz and John H Freeman

Neurobiology of learning and memory, Vol.136, pp.228-235

12/2016

DOI: 10.1016/j.nlm.2016.11.002

PMCID: PMC5124493

PMID: 27818269

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http://doi.org/10.1016/j.nlm.2016.11.002View

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Abstract

Cannabinoid receptors contribute to learning and synaptic plasticity mechanisms. The cerebellum contains a high density of cannabinoid receptors and manipulations of cannabinoid receptors affect synaptic plasticity within the cerebellar cortex. In vivo studies have found that cannabinoid agonists impair learning of cerebellum-dependent eyeblink conditioning in rodents and humans. However, the role of cannabinoid receptors or endocannabinoids in memory consolidation within the cerebellum has not been examined. In the current study, we examined the role of cannabinoid receptors and endocannabinoids during learning and consolidation of eyeblink conditioning in rats. Administration of the cannabinoid receptor agonist WIN55,212-2 or drugs that increase/decrease endocannabinoid levels directly into the cerebellar cortex before each training session resulted in marked learning impairments. When administered 1 h after each training session, during memory consolidation, the cannabinoid inverse agonist SR141716A or the endocannabinoid suppressor THL impaired memory. In contrast, increasing endocannabinoid levels with JZL-184 or infusion of WIN55,212-2 within the cerebellar cortex facilitated memory consolidation 1h post-training. Intracerebellar manipulations of cannabinoid receptors or endocannabinoid levels had no effect on memory consolidation when administered 3 or 6h after each training session. The results demonstrate that cannabinoids impair cerebellar learning, but facilitate memory consolidation mechanisms within the cerebellar cortex 1-3h after training.

Endocannabinoids - metabolism

Memory Consolidation - drug effects

Cerebellar Cortex - metabolism

Rats, Long-Evans

Morpholines - pharmacology

Rats

Male

Cannabinoid Receptor Agonists - pharmacology

Naphthalenes - pharmacology

Receptors, Cannabinoid - metabolism

Animals

Receptor, Cannabinoid, CB1 - agonists

Conditioning, Operant - drug effects

Piperidines - pharmacology

Rimonabant

Benzoxazines - pharmacology

Cannabinoid Receptor Antagonists - pharmacology

Pyrazoles - pharmacology

Details

Title: Subtitle: Cannabinoid modulation of memory consolidation within the cerebellum
Creators: Adam B Steinmetz - Center for Neural Science, New York University, New York, NY, USA
John H Freeman - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA. Electronic address: john-freeman@uiowa.edu
Resource Type: Journal article
Publication Details: Neurobiology of learning and memory, Vol.136, pp.228-235
DOI: 10.1016/j.nlm.2016.11.002
PMID: 27818269
PMCID: PMC5124493
NLM abbreviation: Neurobiol Learn Mem
ISSN: 1074-7427
eISSN: 1095-9564
Publisher: United States
Grant note: R01 MH080005 / NIMH NIH HHS R01 NS088567 / NINDS NIH HHS
Language: English
Date published: 12/2016
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065754402771

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