Journal article
Cannabis use and age at onset of symptoms in subjects at clinical high risk for psychosis
Acta psychiatrica Scandinavica, Vol.125(1), pp.45-53
Accepted for publication July 12, 2011
01/2012
DOI: 10.1111/j.1600-0447.2011.01763.x
PMID: 21883099
Abstract
Objective: Numerous studies have found a robust association between cannabis use and the onset of psychosis. Nevertheless, the relationship between cannabis use and the onset of early (or, in retrospect, prodromal) symptoms of psychosis remains unclear. The study focused on investigating the relationship between cannabis use and early and high-risk symptoms in subjects at clinical high risk for psychosis.
Method: Prospective multicenter, naturalistic field study with an 18-month follow-up period in 245 help-seeking individuals clinically at high risk. The Composite International Diagnostic Interview was used to assess their cannabis use. Age at onset of high risk or certain early symptoms was assessed retrospectively with the Interview for the Retrospective Assessment of the Onset of Schizophrenia.
Results: Younger age at onset of cannabis use or a cannabis use disorder was significantly related to younger age at onset of six symptoms (0.33 < r(s) < 0.83, 0.004 < P < 0.001). Onset of cannabis use preceded symptoms in most participants.
Conclusion: Our results provide support that cannabis use plays an important role in the development of psychosis in vulnerable individuals. Cannabis use in early adolescence should be discouraged.
Details
- Title: Subtitle
- Cannabis use and age at onset of symptoms in subjects at clinical high risk for psychosis
- Creators
- S Dragt - Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the NetherlandsD. H Nieman - Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the NetherlandsF Schultze-Lutter - University Hospital of Child and Adolescent Psychiatry, University of Berne, Berne, SwitzerlandF van der Meer - Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the NetherlandsH Becker - Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the NetherlandsL de Haan - Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the NetherlandsP. M Dingemans - Mediant, Enschedé, the NetherlandsM Birchwood - School of Psychology, University of Birmingham, Birmingham, UKP Patterson - School of Psychology, University of Birmingham, Birmingham, UKR. K. R Salokangas - Department of Psychiatry, University of Turku, Turku, FinlandM Heinimaa - Department of Psychiatry, University of Turku, Turku, FinlandA Heinz - Department of Psychiatry and Psychotherapy, Charité University Medical Center, BerlinG Juckel - Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University Bochum, BochumH Graf von Reventlow - Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Ruhr-University Bochum, BochumP French - Department of Psychiatry, Greater Manchester West Mental Health Trust and School of Psychological Sciences, University of Manchester, Manchester, UKH Stevens - Department of Psychiatry, Greater Manchester West Mental Health Trust, Manchester, UKS Ruhrmann - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, GermanyJ Klosterkötter - Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, GermanyD. H Linszen - Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
- Resource Type
- Journal article
- Publication Details
- Acta psychiatrica Scandinavica, Vol.125(1), pp.45-53
- Edition
- Accepted for publication July 12, 2011
- Publisher
- Blackwell Publishing Ltd; Oxford, UK
- DOI
- 10.1111/j.1600-0447.2011.01763.x
- PMID
- 21883099
- ISSN
- 0001-690X
- eISSN
- 1600-0447
- Number of pages
- 9
- Language
- English
- Date published
- 01/2012
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984072092902771
Metrics
26 Record Views