Journal article
Capacitance of the rabbit portal vein and inferior vena cava
The Journal of physiology, Vol.381(1), pp.417-425
1986
DOI: 10.1113/jphysiol.1986.sp016335
PMCID: PMC1182987
PMID: 3625540
Abstract
1. We used vessel strips and whole vessels in vitro to determine the length-tension and pressure-volume relationships of two veins with similar diameter and wall thickness, the portal vein and inferior vena cava of rabbits. 2. Length-tension studies indicate that longitudinal and circular strips of the portal vein have significantly smaller elastic moduli than similar strips of the inferior vena cava (P less than 0.05). 3. Pressure-volume relationships of intact vessels indicate that pressures greater than 5 mmHg do not produce significant increases in volume of the inferior vena cava, whereas volume of the portal vein increases significantly over a range of pressures from 2 to 15 mmHg. 4. Activation of smooth muscle with noradrenaline reduces the volume of the vena cava at distending pressures less than or equal to 5 mmHg. In contrast, noradrenaline reduces the volume of the portal vein at pressures up to 10 mmHg. During inactivation in calcium-free solution and activation with noradrenaline, the portal vein is more compliant than the inferior vena cava (P less than 0.05). 5. Morphometric studies demonstrate more collagen in the inferior vena cava than in the portal vein. Differences in capacitance of the vessels may be related, in part, to greater collagen content in the inferior vena cava.
Details
- Title: Subtitle
- Capacitance of the rabbit portal vein and inferior vena cava
- Creators
- B. P BROWN - Univ. Iowa, coll. medicine, Iowa City IA 52242, United StatesD. D HEISTAD - Univ. Iowa, coll. medicine, Iowa City IA 52242, United States
- Resource Type
- Journal article
- Publication Details
- The Journal of physiology, Vol.381(1), pp.417-425
- Publisher
- Blackwell; Oxford
- DOI
- 10.1113/jphysiol.1986.sp016335
- PMID
- 3625540
- PMCID
- PMC1182987
- ISSN
- 0022-3751
- eISSN
- 1469-7793
- Language
- English
- Date published
- 1986
- Academic Unit
- Radiology; Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040560902771
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