Capacity-speed relationships in prefrontal cortex

Vivek Prabhakaran; Bart Rypma; Nandakumar S Narayanan; Timothy B Meier; Benjamin P Austin; Veena A Nair; Lin Naing; Lisa E Thomas; John D E Gabrieli

doi:10.1371/journal.pone.0027504

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Capacity-speed relationships in prefrontal cortex

Journal article

Open access

Peer reviewed

Capacity-speed relationships in prefrontal cortex

Vivek Prabhakaran, Bart Rypma, Nandakumar S Narayanan, Timothy B Meier, Benjamin P Austin, Veena A Nair, Lin Naing, Lisa E Thomas and John D E Gabrieli

PloS one, Vol.6(11), pp.e27504-e27504

2011

DOI: 10.1371/journal.pone.0027504

PMCID: PMC3223164

PMID: 22132105

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Abstract

Working memory (WM) capacity and WM processing speed are simple cognitive measures that underlie human performance in complex processes such as reasoning and language comprehension. These cognitive measures have shown to be interrelated in behavioral studies, yet the neural mechanism behind this interdependence has not been elucidated. We have carried out two functional MRI studies to separately identify brain regions involved in capacity and speed. Experiment 1, using a block-design WM verbal task, identified increased WM capacity with increased activity in right prefrontal regions, and Experiment 2, using a single-trial WM verbal task, identified increased WM processing speed with increased activity in similar regions. Our results suggest that right prefrontal areas may be a common region interlinking these two cognitive measures. Moreover, an overlap analysis with regions associated with binding or chunking suggest that this strategic memory consolidation process may be the mechanism interlinking WM capacity and WM speed.

Young Adult

Magnetic Resonance Imaging

Time Factors

Humans

Female

Male

Behavior - physiology

Memory, Short-Term - physiology

Photic Stimulation

Prefrontal Cortex - physiology

Details

Title: Subtitle: Capacity-speed relationships in prefrontal cortex
Creators: Vivek Prabhakaran - Radiology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America. vprabhakaran@uwhealth.org
Bart Rypma
Nandakumar S Narayanan
Timothy B Meier
Benjamin P Austin
Veena A Nair
Lin Naing
Lisa E Thomas
John D E Gabrieli
Resource Type: Journal article
Publication Details: PloS one, Vol.6(11), pp.e27504-e27504
DOI: 10.1371/journal.pone.0027504
PMID: 22132105
PMCID: PMC3223164
NLM abbreviation: PLoS One
ISSN: 1932-6203
eISSN: 1932-6203
Publisher: Public Library of Science; United States
Grant note: RC1 MH090912 / NIMH NIH HHS UL1RR025011 / NCRR NIH HHS RC1MH090912-01 / NIMH NIH HHS R01 DC05375 / NIDCD NIH HHS UL1 RR025011 / NCRR NIH HHS R01 DC005375 / NIDCD NIH HHS
Language: English
Date published: 2011
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984020880602771

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