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Capgras Syndrome in Advanced Parkinson's Disease
Journal article   Open access   Peer reviewed

Capgras Syndrome in Advanced Parkinson's Disease

Christopher L. Groth, Antonia Pusso, Scott A. Sperling, Diane S. Huss, W. Jeffrey Elias, G. Frederick Wooten and Matthew J. Barrett
The journal of neuropsychiatry and clinical neurosciences, Vol.30(2), pp.160-163
03/01/2018
DOI: 10.1176/appi.neuropsych.17030052
PMID: 29132271
url
https://doi.org/10.1176/appi.neuropsych.17030052View
Published (Version of record) Open Access

Abstract

Psychosis is common in Parkinson's disease (PD), especially in advanced disease, and can lead to a number of psychotic symptoms, including delusions. One uncommon delusion is Capgras syndrome (CS). The authors report on three PD patients with a history of deep brain stimulation (DBS) who developed this delusion. The anatomic targets in these three patients were the subthalamic nuclei in two patients and the globus pallidus interna in one patient. The length of time between surgery and development of CS varied but was greater than 6 months. Additionally, all three patients showed evidence of impaired cognition prior to development of CS. Therefore, due to the length of time between DBS and CS in all three cases and the fact that one patient developed CS months after DBS explanation, DBS does not appear to be associated with CS. Given the distressing nature of this condition, patients with advanced PD who undergo DBS should be regularly screened for symptoms of psychosis with awareness of CS as a potential form.
 Clinical Neurology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Psychiatry Science & Technology

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