Journal article
Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor
Brain research, Vol.772(1), pp.82-86
1997
DOI: 10.1016/S0006-8993(97)00876-7
PMID: 9406958
Abstract
Protein kinase C (PKC) has been shown to be involved in nociceptive transmission in the spinal cord. This study tested the hypothesis that induction of central sensitization in the dorsal horn by an intradermal capsaicin injection involves activation of PKC. A PKC inhibitor (NPC15437) was infused through a microdialysis fiber into the spinal cord prior to capsaicin injection. The responses of spinothalamic tract (STT) cells were recorded before and after infusion of NPC15437, and after injection of capsaicin. STT cells show an increased background activity and increased responses to innocuous stimuli following capsaicin injection while responses to heat are decreased. Spinal infusion of the PKC inhibitor, NPC15437, had no effect on background activity or responses to peripherally applied stimuli prior to capsaicin injection. However, NPC15437 prevented the sensitization of cells to weak mechanical stimuli (brush and pressure) that occurs following capsaicin injection. NPC15437 had no effect on the increased background activity or decreased responses to heat stimuli induced by capsaicin injection, suggesting alternative mechanisms for these responses. These data suggest that PKC is important for the development of central sensitization to peripheral mechanical stimuli.
Details
- Title: Subtitle
- Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor
- Creators
- Kathleen A Sluka - Physical Therapy Graduate Program, The University of Iowa, 2600 Steindler Bldg., Iowa City, IA 52242, USAHuw Rees - Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1069, USAPing-Sun Chen - Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1069, USAMasayoshi Tsuruoka - Department of Physiology, Showa University School of Dentistry, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142, JapanWilliam D Willis - Marine Biomedical Institute, University of Texas Medical Branch, 301 University Blvd., Galveston, TX 77555-1069, USA
- Resource Type
- Journal article
- Publication Details
- Brain research, Vol.772(1), pp.82-86
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0006-8993(97)00876-7
- PMID
- 9406958
- ISSN
- 0006-8993
- eISSN
- 1872-6240
- Language
- English
- Date published
- 1997
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040222102771
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