Journal article
Carbapenem-resistant Serratia marcescens isolates producing Bush group 2f β-lactamase (SME-1) in the United States: results from the MYSTIC Programme
Diagnostic microbiology and infectious disease, Vol.39(2), pp.125-127
2001
DOI: 10.1016/S0732-8893(00)00222-4
PMID: 11248526
Abstract
Two carbapenem (imipenem, meropenem)-resistant
Serratia marcescens strains were isolated in the United States (Chicago, IL) through the 1999 MYSTIC (Meropenem Yearly Susceptibility Test Information Collection) Programme. The
S. marcescens antimicrobial susceptible patterns were: susceptible to ceftriaxone, ceftazidime, and cefepime (MICs, ≤0.25 μg/ml), and resistance to the carbapenems (imipenem and meropenem; MIC, > 32 μg/ml) and aztreonam (MIC, ≥16 μg/ml). Each
S. marcescens isolate shared an identical epidemiologic type (ribotype and PFGE) and the outer membrane protein profile was also identical to those of the wild type susceptible strains from the same medical center. The PCR utilizing
bla
sme-1 primers amplified a gene product that was identified as consistent with SME-1 after DNA sequencing. Imipenem and meropenem resistance due to production of carbapenem-hydrolyzing enzymes among clinical isolates is still very rare, but microbiology laboratories should be aware of these chromosomally encoded enzymes among class C β-lactamases producing enteric bacilli such as
S. marcescens and
Enterobacter cloacae.
Details
- Title: Subtitle
- Carbapenem-resistant Serratia marcescens isolates producing Bush group 2f β-lactamase (SME-1) in the United States: results from the MYSTIC Programme
- Creators
- Ana C Gales - Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USADouglas J Biedenbach - Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USAPatricia Winokur - Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, Iowa, USADonna M Hacek - Departments of Medicine and Pathology, Northwestern University, Chicago, Illinois, USAMichael A Pfaller - Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USARonald N Jones - Department of Pathology, University of Iowa College of Medicine, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Diagnostic microbiology and infectious disease, Vol.39(2), pp.125-127
- Publisher
- Elsevier Inc
- DOI
- 10.1016/S0732-8893(00)00222-4
- PMID
- 11248526
- ISSN
- 0732-8893
- eISSN
- 1879-0070
- Language
- English
- Date published
- 2001
- Academic Unit
- Infectious Diseases; Epidemiology; Pathology; Medicine Administration; Internal Medicine
- Record Identifier
- 9984094705402771
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