Journal article
Carbaryl exposure and incident cancer in the Agricultural Health Study
International journal of cancer, Vol.121(8), pp.1799-1805
10/15/2007
DOI: 10.1002/ijc.22836
PMID: 17534892
Abstract
Carbaryl is a carbamate insecticide with a broad spectrum of uses in agricultural, commercial and household settings. It has previously been linked with non-Hodgkin lymphoma (NHL) but studies of cancer risk in humans are limited. We examined occupational carbaryl use and risk of all cancers in the Agricultural Health Study, a prospective study of a cohort of pesticide applicators in North Carolina and Iowa. This analysis included 21,416 subjects (1,291 cases) enrolled from 1993-1997 and followed for cancer incidence through 2003. Pesticide exposure and other data were collected using self-administered questionnaires. Poisson regression was used to calculate rate ratios (RRs) and 95% confidence intervals (CIs) while controlling for potential confounders. Carbaryl was not associated with cancer risk overall. Relative to subjects who never used carbaryl, melanoma risk was elevated with >175 lifetime exposure-days (RR = 4.11; 95%CI, 1.33-12.75; p-trend = 0.07), >10 years of use (RR = 3.19; 95%CI, 1.28-7.92; p-trend = 0.04), or >or=10 days of use per year (RR = 5.50; 95%CI, 2.19-13.84; p-trend < 0.001). Risk remained after adjusting for sunlight exposure. Although not significant, there appeared to be a trend of decreasing prostate cancer risk with increasing level of exposure. A small increase in NHL risk was observed using some, but not all, exposure measures. No associations were observed with other examined cancer sites. Because the observed results were not hypothesized a priori and because of limited study of their biological plausibility, they should be interpreted with caution.
Details
- Title: Subtitle
- Carbaryl exposure and incident cancer in the Agricultural Health Study
- Creators
- Rajeev Mahajan - Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852, USAAaron BlairJoseph CobleCharles F LynchJane A HoppinDale P SandlerMichael C R Alavanja
- Resource Type
- Journal article
- Publication Details
- International journal of cancer, Vol.121(8), pp.1799-1805
- Publisher
- United States
- DOI
- 10.1002/ijc.22836
- PMID
- 17534892
- ISSN
- 0020-7136
- eISSN
- 1097-0215
- Grant note
- Intramural NIH HHS
- Language
- English
- Date published
- 10/15/2007
- Academic Unit
- Epidemiology
- Record Identifier
- 9983995112702771
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