Journal article
Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission
Proceedings of the National Academy of Sciences - PNAS, Vol.101(8), pp.2631-2635
02/24/2004
DOI: 10.1073/pnas.0308695100
PMCID: PMC357001
PMID: 14983060
Abstract
Carbon monoxide (CO) synthesized by heme oxygenase 2 (HO2) and nitric oxide (NO) produced by neuronal NO synthase (nNOS) mediate nonadrenergic/noncholinergic (NANC) intestinal relaxation. In many areas of the gastrointestinal tract, NO and CO function as coneurotransmitters. In the internal anal sphincter (IAS), NANC relaxation is mediated primarily by CO. Vasoactive intestinal polypeptide (VIP) has also been shown to participate in NANC relaxation throughout the intestine, including the IAS. By using a combination of pharmacology and genetic knockout of the biosynthetic enzymes for CO and NO, we show that the physiologic effects of exogenous and endogenous VIP in the IAS are mediated by HO2-synthesized CO.
Details
- Title: Subtitle
- Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission
- Creators
- Crystal C. Watkins - Johns Hopkins UniversityDarren Boehning - Vanderbilt University Medical CenterAdam I. Kaplin - Vanderbilt University Medical CenterMahil Rao - Vanderbilt University Medical CenterChristopher D. Ferris - Vanderbilt University Medical CenterSolomon H. Snyder - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, Vol.101(8), pp.2631-2635
- DOI
- 10.1073/pnas.0308695100
- PMID
- 14983060
- PMCID
- PMC357001
- NLM abbreviation
- Proc Natl Acad Sci U S A
- ISSN
- 0027-8424
- eISSN
- 1091-6490
- Publisher
- National Academy of Sciences
- Number of pages
- 5
- Language
- English
- Date published
- 02/24/2004
- Academic Unit
- Critical Care; Stead Family Department of Pediatrics
- Record Identifier
- 9984775276202771
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