Journal article
Cardiac Arrhythmias: From (Transgenic) Mice to Men
Journal of cardiovascular electrophysiology, Vol.12(9), pp.1089-1091
09/2001
DOI: 10.1046/j.1540-8167.2001.01089.x
PMID: 11573703
Abstract
Cardiac Arrhythmias. Transgenic and gene‐targeted mice now are frequently used to study cardiac arrhythmias due to the ease with which the mouse genome can be manipulated. Marked electrophysiologic differences are present between the mouse and human heart, however, and the utility of the mouse as a model for arrhythmias and sudden death remains controversial. Tachyarrhythmias, bradyarrhythmias, and ECG in the mouse need to be interpreted with extreme care and without preconceptions based on our experience with humans. Despite its limitations, the mouse can provide a powerful tool to further our understanding of basic mechanisms that underlie human cardiac electrophysiology.
Details
- Title: Subtitle
- Cardiac Arrhythmias: From (Transgenic) Mice to Men
- Creators
- Barry London
- Resource Type
- Journal article
- Publication Details
- Journal of cardiovascular electrophysiology, Vol.12(9), pp.1089-1091
- Publisher
- Blackwell Science Inc; Oxford, UK
- DOI
- 10.1046/j.1540-8167.2001.01089.x
- PMID
- 11573703
- ISSN
- 1045-3873
- eISSN
- 1540-8167
- Number of pages
- 3
- Language
- English
- Date published
- 09/2001
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984025683302771
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