Journal article
Cardiac Microvascular Rarefaction in Hyperthyroidism-Induced Left Ventricle Dysfunction
Microcirculation (New York, N.Y. 1994), Vol.20(7), pp.590-598
10/01/2013
DOI: 10.1111/micc.12057
PMID: 23510303
Abstract
Objective
The pathophysiology underlying hyperthyroidism-induced left ventricle (LV) dysfunction and hypertrophy directly involves the heart and indirectly involves the neuroendocrine systems. The effects of hyperthyroidism on the microcirculation are still controversial in experimental models. We investigated the effects of hyperthyroidism on the cardiac function and microcirculation of an experimental rat model.
Methods
Male Wistar rats (170–250 g) were divided into two groups: the euthyroid group (n = 10), which was treated with 0.9% saline solution, and the hyperthyroid group (n = 10), which was treated with l-thyroxine (600 μg/kg/day, i.p.) during 14 days. An echocardiographic study was performed to evaluate the alterations in cardiac function, structure and geometry. The structural capillary density and the expression of angiotensin II AT1 receptor in the LV were analyzed using histochemistry and immunohistochemistry, respectively.
Results
Hyperthyroidism was found to induce profound cardiovascular alterations, such as systolic hypertension, tachycardia, LV dysfunction, cardiac hypertrophy, and myocardial fibrosis. This study demonstrates the existence of structural capillary rarefaction and the down-regulation of the cardiac angiotensin II AT1 receptor in the myocardium of hyperthyroid rats in comparison with euthyroid rats.
Conclusions
Microvascular rarefaction may be involved in the pathophysiology of hyperthyroidism-induced cardiovascular alterations.
Details
- Title: Subtitle
- Cardiac Microvascular Rarefaction in Hyperthyroidism-Induced Left Ventricle Dysfunction
- Creators
- Felipe Freitas - Fundação Oswaldo CruzVanessa Estato - Fundação Oswaldo CruzVinicius Frias Carvalho - Fundação Oswaldo CruzRafael Carvalho Torres - Fundação Oswaldo CruzMarcos Adriano Lessa - University of Iowa, AnesthesiaEduardo Tibirica - Fundação Oswaldo Cruz
- Resource Type
- Journal article
- Publication Details
- Microcirculation (New York, N.Y. 1994), Vol.20(7), pp.590-598
- Publisher
- Wiley
- DOI
- 10.1111/micc.12057
- PMID
- 23510303
- ISSN
- 1073-9688
- eISSN
- 1549-8719
- Number of pages
- 9
- Grant note
- CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico); Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) Oswaldo Cruz Foundation (Fiocruz) FAPERJ (Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro); Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio De Janeiro (FAPERJ)
- Language
- English
- Date published
- 10/01/2013
- Academic Unit
- Anesthesia
- Record Identifier
- 9984656528802771
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