Journal article
Cardiac Troponins: Bench to Bedside Interpretation in Cardiac Disease
The American journal of the medical sciences, Vol.347(4), pp.331-337
04/2014
DOI: 10.1097/MAJ.0b013e31829107ea
PMID: 23656921
Abstract
Cardiac troponins are the preferred biomarkers for the determination of acute myocardial necrosis. The high sensitivity of the available assays has significantly increased the detection of microscopic amounts of myocardial damage. Although compelling evidence indicates that elevated cardiac troponins are markers of poor prognosis and increased mortality, irrespective of the clinical scenario, small elevations can be seen in protean conditions and may confound the diagnosis of acute coronary syndromes. Emerging evidence suggests multiple different cellular mechanisms leading to cardiac troponin release, which challenge long held paradigms such as equivalency between troponin release into the circulation and irreversible cell death. Hence, knowledge of the physiology and pathophysiology of these cardiac biomarkers is essential for their accurate interpretation and consequent correct clinical diagnosis. Herein, the current relevant information about cardiac troponins is discussed, with special emphasis on pathophysiology and clinical correlates.
Details
- Title: Subtitle
- Cardiac Troponins: Bench to Bedside Interpretation in Cardiac Disease
- Creators
- Vasundhara Muthu - SUNY Upstate Medical UniversityHani Kozman - SUNY Upstate Medical UniversityKan Liu - SUNY Upstate Medical UniversityHarold Smulyan - SUNY Upstate Medical UniversityDaniel Villarreal - SUNY Upstate Medical University
- Resource Type
- Journal article
- Publication Details
- The American journal of the medical sciences, Vol.347(4), pp.331-337
- Publisher
- Elsevier Inc
- DOI
- 10.1097/MAJ.0b013e31829107ea
- PMID
- 23656921
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- Language
- English
- Date published
- 04/2014
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318700702771
Metrics
14 Record Views