Cardiac aging in mice and humans: the role of mitochondrial oxidative stress

Dao-Fu Dai; Peter S Rabinovitch

doi:10.1016/j.tcm.2009.12.004

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Cardiac aging in mice and humans: the role of mitochondrial oxidative stress

Journal article

Open access

Peer reviewed

Cardiac aging in mice and humans: the role of mitochondrial oxidative stress

Dao-Fu Dai and Peter S Rabinovitch

Trends in cardiovascular medicine, Vol.19(7), pp.213-220

10/2009

DOI: 10.1016/j.tcm.2009.12.004

PMCID: PMC2858758

PMID: 20382344

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Abstract

Age is a major risk factor for cardiovascular diseases, not only because it prolongs exposure to several other cardiovascular risks, but also owing to intrinsic cardiac aging, which reduces cardiac functional reserve, predisposes the heart to stress, and contributes to increased cardiovascular mortality in the elderly. Intrinsic cardiac aging in the murine model closely recapitulates age-related cardiac changes in humans, including left ventricular hypertrophy, fibrosis, and diastolic dysfunction. Cardiac aging in mice is accompanied by accumulation of mitochondrial protein oxidation, increased mitochondrial DNA mutations, increased mitochondrial biogenesis, as well as decreased cardiac SERCA2 protein. All of these age-related changes are significantly attenuated in mice overexpressing catalase targeted to mitochondria. These findings demonstrate the critical role of mitochondrial reactive oxygen species in cardiac aging and support the potential application of mitochondrial antioxidants to cardiac aging and age-related cardiovascular diseases.

Heart - physiopathology

Endocrine System - physiology

Mitochondria, Heart - metabolism

Reactive Oxygen Species - metabolism

Heart Diseases - physiopathology

Antioxidants - metabolism

Oxidative Stress - physiology

Oxidative Stress - genetics

Animals

Heart Diseases - therapy

Mice

Receptors, Adrenergic - physiology

Mitochondria, Heart - genetics

Aging - metabolism

Details

Title: Subtitle: Cardiac aging in mice and humans: the role of mitochondrial oxidative stress
Creators: Dao-Fu Dai - Department of Pathology, University of Washington, Seattle, WA 98195, USA
Peter S Rabinovitch
Resource Type: Journal article
Publication Details: Trends in cardiovascular medicine, Vol.19(7), pp.213-220
DOI: 10.1016/j.tcm.2009.12.004
PMID: 20382344
PMCID: PMC2858758
NLM abbreviation: Trends Cardiovasc Med
ISSN: 1050-1738
eISSN: 1873-2615
Publisher: United States
Grant note: P30 AG013280-15 / NIA NIH HHS P01 AG001751 / NIA NIH HHS P30 AG013280 / NIA NIH HHS P01 AG001751-24 / NIA NIH HHS
Language: English
Date published: 10/2009
Academic Unit: Pathology; Iowa Neuroscience Institute; Radiation Oncology
Record Identifier: 9984046935602771

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