Cardiac autonomic modulation and blood pressure responses to isometric handgrip and submaximal cycling exercise in individuals with down syndrome

Kanokwan Bunsawat; Tracy Baynard

doi:10.1007/s10286-016-0361-y

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Cardiac autonomic modulation and blood pressure responses to isometric handgrip and submaximal cycling exercise in individuals with down syndrome

Journal article

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Cardiac autonomic modulation and blood pressure responses to isometric handgrip and submaximal cycling exercise in individuals with down syndrome

Kanokwan Bunsawat and Tracy Baynard

Clinical autonomic research, Vol.26(4), pp.253-260

08/01/2016

DOI: 10.1007/s10286-016-0361-y

PMID: 27165540

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Abstract

Individuals with Down syndrome (DS) exhibit autonomic dysfunction, manifested as attenuated heart rate (HR) and blood pressure (BP) responses to sympathoexcitation. Whether a subgroup of individuals with DS with a normal HR response would have normal autonomic responses to sympathoexcitation remains unclear. We compared autonomic modulation using HR variability (HRV) and BP responses in individuals with and without DS (controls) matched for the HR change to isometric handgrip (HG) (10 DS, 8 controls) and submaximal cycling exercise (CE) (9 DS, 9 controls). HG was performed for 2 min at 30 % of maximal voluntary contraction. CE included two 6-min stages at 0 W and at 50 % of body weight. Beat-to-beat HR and BP were recorded. HRV variables were natural log transformation (Ln) of low frequency (LF), high frequency (HF), LF/HF ratio, total power (TP), and the root mean square of successive differences (RMSSD). In the HG study, although individuals with DS exhibited an overall lower systolic BP, LF/HF ratio, and LnLF/LnHF, their BP and HRV responses to HG were similar to those of the controls. In the CE study, individuals with DS exhibited lower resting LnLF and an overall lower systolic BP and mean arterial pressure compared with controls. During the CE, individuals with DS exhibited an increased diastolic BP and a smaller reduction in LnTP than controls. These differences disappeared after controlling for confounders. Our results suggest that despite normal HR responses to sympathoexcitatory tasks, HRV was largely similar to controls, with some evidence of autonomic dysfunction in individuals with DS.

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Details

Title: Subtitle: Cardiac autonomic modulation and blood pressure responses to isometric handgrip and submaximal cycling exercise in individuals with down syndrome
Creators: Kanokwan Bunsawat - University of Illinois Chicago
Tracy Baynard - University of Illinois Urbana-Champaign
Resource Type: Journal article
Publication Details: Clinical autonomic research, Vol.26(4), pp.253-260
DOI: 10.1007/s10286-016-0361-y
PMID: 27165540
NLM abbreviation: Clin Auton Res
ISSN: 0959-9851
eISSN: 1619-1560
Publisher: Springer Nature
Number of pages: 8
Grant note: American Heart Association
Language: English
Date published: 08/01/2016
Academic Unit: Health, Sport, and Human Physiology
Record Identifier: 9984948043102771

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