Cardiac dysfunction and cognition in older adults with heart failure

Karin F Hoth; Athena Poppas; David J Moser; Robert H Paul; Ronald A Cohen

doi:10.1097/wnn.0b013e3181799dc8

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Cardiac dysfunction and cognition in older adults with heart failure

Journal article

Peer reviewed

Cardiac dysfunction and cognition in older adults with heart failure

Karin F Hoth, Athena Poppas, David J Moser, Robert H Paul and Ronald A Cohen

Cognitive and behavioral neurology, Vol.21(2), pp.65-72

06/2008

DOI: 10.1097/wnn.0b013e3181799dc8

PMID: 18541980

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Abstract

To characterize cognition in patients with moderate to severe heart failure and examine the association between 2 measures of systemic perfusion (ie, ejection fraction and cardiac index) and cognition. Decreased systemic perfusion has been implicated as an etiologic factor in the development of cognitive deficits in cardiovascular disease. Thirty-one patients with moderate to severe heart failure and 31 patients with cardiovascular disease and no heart failure completed a medical history interview and neuropsychologic assessment. Participants with heart failure additionally underwent an echocardiogram to assess cardiac function. Patients with heart failure performed significantly worse than the cardiovascular disease-no heart failure group on several measures of executive functioning and psychomotor speed. Among the heart failure group, lower ejection fraction was associated with weaker global cognition, performance on several, but not all, measures of executive functioning, and was marginally associated with delayed memory. Decreased cardiac index was associated with poorer immediate memory and weakly associated with global cognition. Findings suggest that depressed systemic perfusion is associated with cognitive deficits among patients with heart failure. Research including measures of cardiac function, cerebral perfusion, and cognition will be necessary to clarify the causal nature of the suggested mechanism.

Humans

Male

Reference Values

Hemodynamics - physiology

Psychomotor Performance - physiology

Attention - physiology

Brain - blood supply

Cardiovascular Diseases - complications

Cognition Disorders - etiology

Female

Heart Failure - diagnosis

Heart Failure - psychology

Cardiovascular Diseases - diagnosis

Cognition Disorders - psychology

Heart Failure - complications

Cognition Disorders - physiopathology

Echocardiography

Risk Factors

Problem Solving - physiology

Brain Ischemia - physiopathology

Brain Ischemia - etiology

Reaction Time - physiology

Cardiac Output, Low - complications

Cardiac Output, Low - psychology

Neuropsychological Tests

Cognition Disorders - diagnosis

Brain Ischemia - psychology

Mental Recall - physiology

Brain Ischemia - diagnosis

Cardiac Output, Low - diagnosis

Aged

Cardiovascular Diseases - psychology

Blood Flow Velocity - physiology

Details

Title: Subtitle: Cardiac dysfunction and cognition in older adults with heart failure
Creators: Karin F Hoth - Division of Psychosocial Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA. hothk@njc.org
Athena Poppas
David J Moser
Robert H Paul
Ronald A Cohen
Resource Type: Journal article
Publication Details: Cognitive and behavioral neurology, Vol.21(2), pp.65-72
DOI: 10.1097/wnn.0b013e3181799dc8
PMID: 18541980
NLM abbreviation: Cogn Behav Neurol
ISSN: 1543-3633
eISSN: 1543-3641
Publisher: United States
Grant note: AG026850 / NIA NIH HHS F32 AG026850 / NIA NIH HHS AG020649 / NIA NIH HHS K23 AG020649 / NIA NIH HHS
Language: English
Date published: 06/2008
Academic Unit: Psychiatry; Iowa Neuroscience Institute; Medicine Administration
Record Identifier: 9984003428402771

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