Cardiac remodeling in obesity

E Dale Abel; Sheldon E Litwin; Gary Sweeney

doi:10.1152/physrev.00017.2007

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Journal article

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Cardiac remodeling in obesity

E Dale Abel, Sheldon E Litwin and Gary Sweeney

Physiological reviews, Vol.88(2), pp.389-419

04/2008

DOI: 10.1152/physrev.00017.2007

PMCID: PMC2915933

PMID: 18391168

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Abstract

The dramatic increase in the prevalence of obesity and its strong association with cardiovascular disease have resulted in unprecedented interest in understanding the effects of obesity on the cardiovascular system. A consistent, but puzzling clinical observation is that obesity confers an increased susceptibility to the development of cardiac disease, while at the same time affording protection against subsequent mortality (termed the obesity paradox). In this review we focus on evidence available from human and animal model studies and summarize the ways in which obesity can influence structure and function of the heart. We also review current hypotheses regarding mechanisms linking obesity and various aspects of cardiac remodeling. There is currently great interest in the role of adipokines, factors secreted from adipose tissue, and their role in the numerous cardiovascular complications of obesity. Here we focus on the role of leptin and the emerging promise of adiponectin as a cardioprotective agent. The challenge of understanding the association between obesity and heart failure is complicated by the multifaceted interplay between various hemodynamic, metabolic, and other physiological factors that ultimately impact the myocardium. Furthermore, the end result of obesity-associated changes in the myocardial structure and function may vary at distinct stages in the progression of remodeling, may depend on the individual pathophysiology of heart failure, and may even remain undetected for decades before clinical manifestation. Here we summarize our current knowledge of this complex yet intriguing topic.

Heart - physiopathology

Animals

Humans

Myocardium - pathology

Obesity - physiopathology

Ventricular Remodeling - physiology

Adipokines - physiology

Disease Models, Animal

Obesity - pathology

Details

Title: Subtitle: Cardiac remodeling in obesity
Creators: E Dale Abel - Department of Biology, York University, Toronto, Canada
Sheldon E Litwin
Gary Sweeney
Resource Type: Journal article
Publication Details: Physiological reviews, Vol.88(2), pp.389-419
DOI: 10.1152/physrev.00017.2007
PMID: 18391168
PMCID: PMC2915933
NLM abbreviation: Physiol Rev
ISSN: 0031-9333
eISSN: 1522-1210
Publisher: United States
Grant note: U01-HL-70525 / NHLBI NIH HHS U01 HL070525 / NHLBI NIH HHS R01 HL070070-04 / NHLBI NIH HHS R01 HL070070 / NHLBI NIH HHS R01 DK092065 / NIDDK NIH HHS U01 HL087947 / NHLBI NIH HHS U01-HL-087947 / NHLBI NIH HHS R01-HL-73167 / NHLBI NIH HHS U01 HL087947-04 / NHLBI NIH HHS R01-HL-70070 / NHLBI NIH HHS R01 HL073167-05 / NHLBI NIH HHS R01 HL073167 / NHLBI NIH HHS
Language: English
Date published: 04/2008
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Fraternal Order of Eagles Diabetes Research Center; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Internal Medicine
Record Identifier: 9984025271902771

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