Journal article
Cardio-ankle vascular index of increased arterial wall stiffness is associated with neurocognitive impairment in well-controlled HIV
HIV medicine, Vol.23(6), pp.599-610
07/01/2022
DOI: 10.1111/hiv.13213
PMID: 34859556
Abstract
Objectives HIV-associated neurocognitive disorders (HAND) remain prevalent in people living with HIV (PLWH) despite widespread use of combined antiretroviral therapy (ART). Vascular disease contributes to the pathogenesis of HAND, but traditional vascular risk factors do not fully explain the relation between vascular disease and HAND. A more direct measure of vascular dysfunction is needed. This cross-sectional study tested whether the cardio-ankle vascular index (CAVI), a novel method to assess arterial stiffness, is associated with HAND among PLWH. Methods Participants included 75 non-diabetic adults with well-controlled HIV from an outpatient HIV clinic. We assessed the relation between CAVI and neurocognitive impairment (NCI). The latter was primarily characterized by the Frascati criteria and secondarily (post hoc) using the Global Deficit Score (GDS). Logistic regression models tested whether high CAVI (>= 8) was independently associated with NCI when controlling for potential confounders. Results Participants (M-age = 45.6 +/- 8.3 years; 30.1% male) had few traditional cardiovascular disease (CVD) risk factors (hypertension, n = 7; dyslipidaemia, n = 34; body mass index >= 25 kg/m(2), n = 12; smoking history, n = 13; 2.2% mean 10-year risk of CVD or stroke). Twelve (16%) participants had high CAVI, which was independently associated with meeting Frascati criteria for NCI [n = 39, odds ratio (OR) = 7.6, p = 0.04], accounting for age, education, gender, income, CD4 nadir, recent CD4 and traditional CVD risk factors. High CAVI was also associated with NCI as reflected by higher GDS (OR = 17.4, p = 0.02). Conclusions Cardio-ankle vascular index is a promising measure of vascular dysfunction that may be independently associated with NCI in relatively healthy PLWH. Larger studies should test the utility of CAVI in predicting NCI/decline in PLWH.
Details
- Title: Subtitle
- Cardio-ankle vascular index of increased arterial wall stiffness is associated with neurocognitive impairment in well-controlled HIV
- Creators
- Quanhathai Kaewpoowat - Roy J. and Lucille A. Carver College of MedicineAmaraporn Rerkasem - Chiang Mai UniversityKittipan Rerkasem - Chiang Mai UniversityKevin R. Robertson - University of North Carolina at Chapel HillStephen L. Aita - Dartmouth CollegeRobert M. Roth - Dartmouth CollegeSaowaluck Yasri - Chiang Mai UniversityJanejit Choovuthayakorn - Chiang Mai UniversitySomsanguan Ausayakhun - Chiang Mai UniversityKhuanchai Supparatpinyo - Chiang Mai UniversityNathaniel M. Robbins - Dartmouth College
- Resource Type
- Journal article
- Publication Details
- HIV medicine, Vol.23(6), pp.599-610
- Publisher
- Wiley
- DOI
- 10.1111/hiv.13213
- PMID
- 34859556
- ISSN
- 1464-2662
- eISSN
- 1468-1293
- Number of pages
- 12
- Grant note
- UL1TR001086 / National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) Research Institute for Health Sciences, Chiang Mai University Dartmouth-Hitchcock Department of Neurology Alexander Reeves Endowment Fund Department of State Fulbright Research Program Chiang Mai University
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359868902771
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