Journal article
Cardiometabolic effects of psychotropic medications
Hormone molecular biology and clinical investigation, Vol.36(1), p.95
01/10/2018
DOI: 10.1515/hmbci-2017-0065
PMCID: PMC6818518
PMID: 29320364
Abstract
Background Many psychiatric disorders including schizophrenia, bipolar disorder and major depression convey an excess burden of cardiovascular morbidity and mortality. The medications used to treat these conditions may further adversely affect cardiovascular risk and exacerbate health disparities for vulnerable populations. There is a clinical need to appreciate the cardiometabolic adverse effects of psychotropic medications. Methods This paper reviews the most relevant cardiometabolic effects of psychotropic medications, organized around the components of metabolic syndrome. When known, the molecular and physiological mechanisms underlying any adverse cardiometabolic effects are detailed. Results Many commonly used psychotropic medications, particularly antipsychotics, mood stabilizers and some antidepressants, have been independently associated with cardiometabolic risk factors such as insulin resistance, obesity and dyslipidemia. Stimulants, antidepressants that inhibit reuptake of norepinephrine, some antipsychotics and valproic acid derivatives may also increase blood pressure. Conclusion Understanding, assessing and subsequently managing cardiometabolic complications of psychotropic medications are important to mitigate the excess cardiovascular morbidity and mortality in the clinical populations prescribed psychotropic medications. There is considerable variability in risk between medications and individuals. Timely management of iatrogenic cardiometabolic effects is critical.
Details
- Title: Subtitle
- Cardiometabolic effects of psychotropic medications
- Creators
- Oluchi Abosi - Department of Psychiatry, The University of Iowa, Iowa City, IA, USASneha Lopes - Department of Psychiatry, The University of Iowa, Iowa City, IA, USASamantha Schmitz - Department of Epidemiology College of Public Health, The University of Iowa, Iowa City, IA, USAJess G Fiedorowicz - Obesity Research and Education Initiative, The University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Hormone molecular biology and clinical investigation, Vol.36(1), p.95
- DOI
- 10.1515/hmbci-2017-0065
- PMID
- 29320364
- PMCID
- PMC6818518
- NLM abbreviation
- Horm Mol Biol Clin Investig
- ISSN
- 1868-1883
- eISSN
- 1868-1891
- Publisher
- Germany
- Grant note
- P01 HL014388 / NHLBI NIH HHS R01 MH111578 / NIMH NIH HHS UL1 TR002345 / NCATS NIH HHS U54 TR001356 / NCATS NIH HHS
- Language
- English
- Date published
- 01/10/2018
- Academic Unit
- Psychiatry; Epidemiology; Iowa Neuroscience Institute
- Record Identifier
- 9984065486702771
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