Journal article
Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats
Canadian journal of anesthesia, Vol.50(9), pp.940-945
11/01/2003
DOI: 10.1007/BF03018744
PMID: 14617594
Abstract
Purpose
Volatile anesthetics can protect the heart against reperfusion injury. When sevoflurane is given for the first 15 min of reperfusion, a concentration corresponding to one minimum alveolar concentration (MAC) provides a maximum protective effect. The present study addresses the question of how long sevoflurane has to be administered to achieve the best cardioprotection.
Methods
Chloralose anesthetized rats were subjected to a 25-min occlusion of a major coronary artery, followed by 90 min of reperfusion. During the initial phase of reperfusion, an end-tidal concentration of 2.4 vol.% of sevoflurane (1 MAC) was given for two (n = 8), five (n = 8) or ten minutes (n =7). Seven rats served as untreated controls. We measured left ventricular (LV) pressure, mean aortic pressure and infarct size (triphenyltetrazolium staining).
Results
Administration of sevoflurane for two minutes resulted in the greatest reduction of infarct size to 15% (8–22 [mean (95% confidence interval)] of the area at risk compared with controls [51 (47–55) %, P < 0.00 1], Five or ten minutes of sevoflurane administration reduced infarct size to 26 ( 18–34) and 26 ( 18–35) % [P < 0.05], respectively. The cardiodepressant effect of sevoflurane varied with the duration of its administration: LV dP/dt was reduced from 6332 mmHg · sec−1 (5771–6894) during baseline to 4211 mmHg · sec−1 (3031–5391), 3811 mmHg · sec−1 (2081–5540) and 3612 mmHg · sec−1 (2864–4359) after two, five and ten minutes of reperfusion, respectively.
Conclusion
Administration of 1 MAC sevoflurane for the first two minutes of reperfusion effectively protects the heart against reperfusion injury in ratsin vivo. A longer administration time had lesser cardioprotective effects in this experimental model.
Details
- Title: Subtitle
- Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats
- Creators
- Detlef Obal - Düsseldorf University HospitalHorst Scharbatke - Heinrich Heine University DüsseldorfHolger Barthel - Heinrich Heine University DüsseldorfBenedikt Preckel - Heinrich Heine University DüsseldorfJost Müllenheim - Heinrich Heine University DüsseldorfWolfgang Schlack - Düsseldorf University Hospital
- Resource Type
- Journal article
- Publication Details
- Canadian journal of anesthesia, Vol.50(9), pp.940-945
- DOI
- 10.1007/BF03018744
- PMID
- 14617594
- NLM abbreviation
- Can J Anaesth
- ISSN
- 0832-610X
- eISSN
- 1496-8975
- Publisher
- Canadian Anesthesiologists' Society
- Language
- English
- Date published
- 11/01/2003
- Academic Unit
- Anesthesia
- Record Identifier
- 9984696563502771
Metrics
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