Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development

David C Merrill; Jeffrey L Segar; Oliva J McWeeny; Bruce A Smith; Jean E Robillard

doi:10.1152/ajpheart.1994.267.4.H1467

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Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development

Journal article

Peer reviewed

Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development

David C Merrill, Jeffrey L Segar, Oliva J McWeeny, Bruce A Smith and Jean E Robillard

American journal of physiology. Heart and circulatory physiology, Vol.267(4), pp.H1467-H1475

10/01/1994

DOI: 10.1152/ajpheart.1994.267.4.H1467

PMID: 7943393

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https://EconPapers.repec.org/RePEc:ovi:oviste:v:xii:y:2012:i:1:p:1035-1038View

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Abstract

Recent studies demonstrated that renal denervation had no effect on the natriuretic response to volume expansion (VE) in fetal sheep, suggesting that the sensitivity of the cardiopulmonary reflex in response to VE is impaired in the fetus. To test this hypothesis, we investigated the renal sympathetic nerve activity (RSNA) and heart rate (HR) responses to 20 and 50% intravascular VE in fetal (130-135 days gestation; term 145 days) (n = 7), newborn (n = 8), and 6- to 8-wk-old sheep (n = 9). Despite similar increases in right atrial pressure (RAP) in the three groups, 20% VE had no significant effect on RSNA and HR in fetal sheep but significantly decreased RSNA in newborn (-22.8 +/- 7.3%) and 6- to 8-wk-old sheep (-32.1 +/- 11.7%). Bradycardic responses to VE were also observed in both newborn (from 237 +/- 6 to 200 +/- 12 beats/min) and 6- to 8-wk-old sheep (from 170 +/- 9 to 140 +/- 9 beats/min). A 50% VE had no significant effect on fetal RSNA and HR, whereas it increased RAP by 6.8 +/- 0.9 mmHg. In addition, we tested the hypothesis that interactions between cardiopulmonary and arterial baroreflexes in response to VE change during development. We found that 20 and 50% VE shifted the RSNA and HR arterial baroreflex response curves to the right in the fetus but had no significant effects on the gain of the arterial baroreflex curves in either fetal, newborn, or 6- to 8-wk-old sheep.

Details

Title: Subtitle: Cardiopulmonary and arterial baroreflex responses to acute volume expansion during fetal and postnatal development
Creators: David C Merrill - University of Iowa Hospitals and Clinics
Jeffrey L Segar - University of Iowa
Oliva J McWeeny - University of Iowa
Bruce A Smith - University of Iowa
Jean E Robillard - University of Iowa
Resource Type: Journal article
Publication Details: American journal of physiology. Heart and circulatory physiology, Vol.267(4), pp.H1467-H1475
DOI: 10.1152/ajpheart.1994.267.4.H1467
PMID: 7943393
NLM abbreviation: Am J Physiol Heart Circ Physiol
ISSN: 0363-6135
eISSN: 1522-1539
Language: English
Date published: 10/01/1994
Academic Unit: Molecular Physiology and Biophysics; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Medicine Administration
Record Identifier: 9984773401302771

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