Journal article
Cardiorespiratory Instability after Percutaneous Patent Ductus Arteriosus Closure: A Multicenter Cohort Study
The Journal of pediatrics, Vol.271, 114052
08/2024
DOI: 10.1016/j.jpeds.2024.114052
PMID: 38615941
Abstract
To evaluate post-procedural clinical characteristics of preterm infants undergoing transcatheter patent ductus arteriosus (PDA) closure, including oxygenation/ventilation failure and cardiovascular compromise
Multicenter retrospective cohort study of preterm infants who were ≤2 kg at the time of percutaneous PDA closure between August 2018 and July 2021. Indices of cardiorespiratory stability were collected pre-closure, immediately post-closure, and subsequently averaged every 4 hours for the first 24 hours post-procedure. The primary outcome was incidence of post-transcatheter cardiorespiratory syndrome: composite of: (i) hemodynamic instability (defined by systemic hypotension, systemic hypertension, or use of new inotropes/vasopressors in the first 24 hours after catheterization and at least one of the following: (i)ventilation failure or (ii) oxygenation failure.
A total of 197 patients were included with a median [IQR] age and weight at catheterization of 34 [25, 43] days and 1090 [900, 1367] grams, respectively. The primary composite outcome was reported in 46 (23.3%) patients and subcomponents of oxygenation and/or ventilation failure, systolic hypotension or systolic hypertension were noted in 81 (41.1%), 3 (1.5%) and 86 (43.6%) respectively. Logistic regression models showed weight at catheterization and respiratory severity score pre-closure to be significantly associated with post-transcatheter cardiorespiratory syndrome.
Post-transcatheter cardiorespiratory syndrome is characterized primarily by systemic hypertension and oxygenation failure, with a very low incidence of hypotension and need for inotropes.
Details
- Title: Subtitle
- Cardiorespiratory Instability after Percutaneous Patent Ductus Arteriosus Closure: A Multicenter Cohort Study
- Creators
- Adrianne R. Bischoff - University of IowaCarl H. Backes - Nationwide Children's HospitalBrian Rivera - Nationwide Children's HospitalBonny Jasani - Hospital for Sick ChildrenForamben Patel - Hospital for Sick ChildrenErica Cheung - Hospital for Sick ChildrenShyam Sathanandam - University of Tennessee Health Science CenterRanjit Philip - University of Tennessee Health Science CenterPatrick J. McNamara - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of pediatrics, Vol.271, 114052
- DOI
- 10.1016/j.jpeds.2024.114052
- PMID
- 38615941
- NLM abbreviation
- J Pediatr
- ISSN
- 0022-3476
- eISSN
- 1097-6833
- Publisher
- Elsevier Inc
- Language
- English
- Electronic publication date
- 04/12/2024
- Date published
- 08/2024
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984586459102771
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