Journal article
Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy
Neurobiology of disease, Vol.127, pp.502-511
07/01/2019
DOI: 10.1016/j.nbd.2019.04.006
PMCID: PMC6588471
PMID: 30974168
Abstract
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, but the relative importance of underlying cardiac and respiratory mechanisms remains unclear. To illuminate the interactions between seizures, respiration, cardiac function, and sleep that contribute to SUDEP risk, here we developed a mouse epilepsy monitoring unit (EMU) to simultaneously record video, electroencephalography (EEG), electromyography (EMG), plethysmography, and electrocardiography (ECG) in a commonly used genetic model of SUDEP, the Kcna1 knockout (Kcna1(-/-)) mouse. During interictal periods, Kcna1(-/-) mice exhibited an abnormal absence of post-sigh apneas and a 3-fold increase in respiratory variability. During spontaneous convulsive seizures, Kcna1(-/-)mice displayed an array of aberrant breathing patterns that always preceded cardiac abnormalities. These findings support respiratory dysfunction as a primary risk factor for susceptibility to deleterious cardiorespiratory sequelae in epilepsy and reveal a new role for Kcna1(-/-)-encoded Kv1.1 channels in the regulation of basal respiratory physiology.
Details
- Title: Subtitle
- Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy
- Creators
- Hemangini Dhaibar - Louisiana State University Health Sciences Center ShreveportNicole M. Gautier - Louisiana State University Health Sciences Center ShreveportOleg Y. Chernyshev - Louisiana State University Health Sciences Center ShreveportPaari Dominic - Louisiana State University Health Sciences Center ShreveportEdward Glasscock - Louisiana State University Health Sciences Center Shreveport
- Resource Type
- Journal article
- Publication Details
- Neurobiology of disease, Vol.127, pp.502-511
- DOI
- 10.1016/j.nbd.2019.04.006
- PMID
- 30974168
- PMCID
- PMC6588471
- NLM abbreviation
- Neurobiol Dis
- ISSN
- 0969-9961
- eISSN
- 1095-953X
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Citizens United for Research in Epilepsy R01NS100954 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS100954; R01NS099188 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Louisiana State University Health Sciences Center- Shreveport
- Language
- English
- Date published
- 07/01/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984366262502771
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