Cardiovascular Risk in HIV-Infected and Uninfected Postmenopausal Minority Women: Use of the Framingham Risk Score

Yamnia I Cortés; Nancy Reame; Cosmina Zeana; Haomiao Jia; David C Ferris; Elizabeth Shane; Michael T Yin

doi:10.1089/jwh.2015.5736

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Cardiovascular Risk in HIV-Infected and Uninfected Postmenopausal Minority Women: Use of the Framingham Risk Score

Journal article

Open access

Peer reviewed

Cardiovascular Risk in HIV-Infected and Uninfected Postmenopausal Minority Women: Use of the Framingham Risk Score

Yamnia I Cortés, Nancy Reame, Cosmina Zeana, Haomiao Jia, David C Ferris, Elizabeth Shane and Michael T Yin

Journal of women's health (Larchmont, N.Y. 2002), Vol.26(3), pp.241-248

03/2017

DOI: 10.1089/jwh.2015.5736

PMCID: PMC5361765

PMID: 27611626

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Abstract

To characterize and compare cardiovascular disease (CVD) risk in HIV-infected and uninfected postmenopausal minority women using the Framingham Risk Score (FRS) as an assessment measure. A cross-sectional analysis was performed in 152 (109 HIV+, 43 HIV-) subjects from an existing study cohort of postmenopausal Hispanic and African American women. Data necessary to calculate FRS and menopause features were retrieved by retrospective chart review. Bivariate statistics was used to compare CVD risk factors. Multivariable linear regression was used to determine factors associated with FRS in HIV-infected women. The HIV-infected group was younger, less obese, and with lower rates of diabetes versus controls. In a subset of age-matched participants, median FRS did not differ between groups (14.6 [IQR = 9.1, 21.6] vs. 15.5 [IQR = 12.3, 22.1]; p = 0.73). Fourteen percent of HIV-infected women meeting criteria for the low-risk FRS category (<10%) had a history of CVD, a similar rate as controls. HIV-infected women at intermediate/high CVD risk had higher rates of surgical menopause. According to 2013 clinical guidelines, more than half of HIV-infected women not prescribed statin therapy (52%) were eligible for treatment; however, statin therapy was similarly under-prescribed in uninfected women. In this study, CVD risk as assessed by the FRS was not significantly different by HIV status. Performance of the FRS may be compromised in postmenopausal HIV-infected minority women. HIV-infected and uninfected women may be undertreated with statin therapy. Large longitudinal cohorts and inclusion of subclinical measures of CVD are necessary to better characterize risk.

African Americans - statistics & numerical data

Aged

Cardiovascular Diseases - epidemiology

Cross-Sectional Studies

Female

Hispanic Americans - statistics & numerical data

HIV Infections - complications

Humans

Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use

Logistic Models

Middle Aged

Multivariate Analysis

Postmenopause

Retrospective Studies

Risk Assessment

Risk Factors

United States

Details

Title: Subtitle: Cardiovascular Risk in HIV-Infected and Uninfected Postmenopausal Minority Women: Use of the Framingham Risk Score
Creators: Yamnia I Cortés - Columbia University
Nancy Reame - Columbia University
Cosmina Zeana - Bronx-Lebanon Hospital Center
Haomiao Jia - Columbia University
David C Ferris - Theodore Roosevelt High School
Elizabeth Shane - Columbia University
Michael T Yin - Columbia University
Resource Type: Journal article
Publication Details: Journal of women's health (Larchmont, N.Y. 2002), Vol.26(3), pp.241-248
DOI: 10.1089/jwh.2015.5736
PMID: 27611626
PMCID: PMC5361765
ISSN: 1540-9996
eISSN: 1931-843X
Grant note: T32 HL083825 / NHLBI NIH HHS
Language: English
Date published: 03/2017
Academic Unit: Nursing
Record Identifier: 9984446549602771

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