Journal article
Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats
European journal of pharmacology, Vol.385(2), pp.199-202
1999
DOI: 10.1016/S0014-2999(99)00705-0
PMID: 10607876
Abstract
In a previous study we showed that in normotensive male rats brain mineralocorticoid receptor blockade induced a long lasting decrease in blood pressure associated with increased urinary excretion of water and electrolytes. Here, we report the effect of intracerebroventricular injection of a mineralocorticoid receptor antagonist (RU28318; 3,3-oxo-7 propyl-17-hydroxy-androstan-4-en-17yl-propionic acid lactone) on cardiovascular and renal function in female rats. Compared with male rats, females are less sensitive to brain mineralocorticoid receptor blockade. Administration of RU28318 (10 ng, 100 ng) caused a significant decrease in systolic blood pressure (10–12.5%) only at 8 h after injection. An increased urinary excretion of water (about 160%) and electrolytes (about 175%) during the first 8 h after the injection was observed in the 100 ng RU28318 treated group. Heart rate, food intake and water consumption were not affected at either dose. In conclusion, in conscious female rats, brain mineralocorticoid receptors participate in blood pressure and renal function control.
Details
- Title: Subtitle
- Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats
- Creators
- Kamal Rahmouni - Institut de Pharmacologie, Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg, CEDEX,FranceMariette Barthelmebs - Institut de Pharmacologie, Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg, CEDEX,FranceMichèle Grima - Institut de Pharmacologie, Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg, CEDEX,FranceJean Louis Imbs - Institut de Pharmacologie, Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg, CEDEX,FranceWybren De Jong - Institut de Pharmacologie, Laboratoire de Pharmacologie-Physiologie Rénovasculaire, Faculté de Médecine, Université Louis Pasteur, 11 rue Humann, 67085 Strasbourg, CEDEX,France
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.385(2), pp.199-202
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0014-2999(99)00705-0
- PMID
- 10607876
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 1999
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040489902771
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