Journal article
Cardiovascular and renal sympathetic activation by blood-borne TNF-α in rat: the role of central prostaglandins
American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(4), pp.R916-R927
04/01/2003
DOI: 10.1152/ajpregu.00406.2002
PMID: 12626358
Abstract
In pathophysiological conditions, increased blood-borne TNF-α induces a broad range of biological effects, including activation of the hypothalamic-pituitary-adrenal axis and sympathetic drive. In urethane-anesthetized adult Sprague-Dawley rats, we examined the mechanisms by which blood-borne TNF-α activates neurons in paraventricular nucleus (PVN) of hypothalamus and rostral ventrolateral medulla (RVLM), two critical brain regions regulating sympathetic drive in normal and pathophysiological conditions. TNF-α (0.5 μg/kg), administered intravenously or into ipsilateral carotid artery (ICA), activated PVN and RLVM neurons and increased sympathetic nerve activity, arterial pressure, and heart rate. Responses to intravenous TNF-α were not affected by vagotomy but were reduced by mid-collicular decerebration. Responses to ICA TNF-α were substantially reduced by injection of the cyclooxygenase inhibitor ketorolac (150 μg) into lateral ventricle. Injection of PGE2 (50 ng) into lateral ventricle or directly into PVN increased PVN or RVLM activity, respectively, and sympathetic drive, with shorter onset latency than blood-borne TNF-α. These findings suggest that blood-borne cytokines stimulate cardiovascular and renal sympathetic responses via a prostaglandin-dependent mechanism operating at the hypothalamic level.
Details
- Title: Subtitle
- Cardiovascular and renal sympathetic activation by blood-borne TNF-α in rat: the role of central prostaglandins
- Creators
- Zhi-Hua Zhang - Department of Internal Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine and Medical ServiceShun-Guang Wei - Department of Internal Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine and Medical ServiceJoseph Francis - Department of Internal Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine and Medical ServiceRobert B Felder - Department of Internal Medicine, University of Iowa, Roy J. and Lucille A. Carver College of Medicine and Medical Service,, Veterans Administration Medical Center, Iowa City, Iowa 52242
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Regulatory, integrative and comparative physiology, Vol.284(4), pp.R916-R927
- DOI
- 10.1152/ajpregu.00406.2002
- PMID
- 12626358
- ISSN
- 0363-6119
- eISSN
- 1522-1490
- Language
- English
- Date published
- 04/01/2003
- Academic Unit
- Iowa Neuroscience Institute; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984065387302771
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