Journal article
Cardiovascular and sympathetic nervous system responses to an acute stressor in borderline hypertensive rats (BHR)
Physiology & behavior, Vol.46(2), pp.309-313
1989
DOI: 10.1016/0031-9384(89)90272-2
PMID: 2602473
Abstract
The present study examined cardiovascular and plasma catecholamine responses to acute footshock stress in adult male Wistar-Kyoto (WKY) normotensive, borderline hypertensive (BHR), and spontaneously hypertensive (SHR) rats. Basal mean arterial pressure and heart rate were equivalent for SHRs and BHRs, and levels for both groups were elevated compared to WKYs. Following transfer to the footshock chamber, blood pressure increased to a greater degree in SHRs than in WKYs or BHRs. However, the tachycardia was exaggerated in both BHRs and SHRs compared to WKYs. In response to intermittent footshock stress, all groups had comparable heart rate increases while maintaining blood pressure near baseline levels. SHRs demonstrated a sympathetic hyperresponsiveness to footshock stress, with greater increases in plasma norepinephrine and epinephrine levels than WKYs immediately following footshock. At 5 minutes postfootshock, plasma catecholamines remained elevated in SHRs over both WKYs and BHRs. Plasma catecholamine increases following footshock were comparable at all time points between WKYs and BHRs. The present results demonstrate that sympathetic responsiveness of BHRs to acute footshock stress is more similar to normotensive WKYs than to hypertensive SHRs.
Details
- Title: Subtitle
- Cardiovascular and sympathetic nervous system responses to an acute stressor in borderline hypertensive rats (BHR)
- Creators
- Robert F Kirby - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242 USAMichael F Callahan - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242 USARichard McCarty - Department of Psychology, University of Virginia, Charlottesville, VA 22903 USAAlan Kim Johnson - Departments of Psychology and Pharmacology and the Cardiovascular Center, University of Iowa, Iowa City, IA 52242 USA
- Resource Type
- Journal article
- Publication Details
- Physiology & behavior, Vol.46(2), pp.309-313
- DOI
- 10.1016/0031-9384(89)90272-2
- PMID
- 2602473
- NLM abbreviation
- Physiol Behav
- ISSN
- 0031-9384
- eISSN
- 1873-507X
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 1989
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; University College Courses; Health, Sport, and Human Physiology
- Record Identifier
- 9984213410902771
Metrics
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