Journal article
Cardiovascular effects of low-oxygen atmospheres in conscious and anesthetized dogs
Journal of applied physiology (1948), Vol.27(3), pp.370-373
09/1969
DOI: 10.1152/jappl.1969.27.3.370
PMID: 5804135
Abstract
A group of conscious dogs, with Doppler ultrasonic flow transducers on the ascending aorta and catheters in the left and right atria, pulmonary
artery, and thoracic aorta, were exposed for 30 min to atmospheres with PO, of 85, 70, 55, or 40 mm Hg in an environmental chamber.
Hypoxia resulted in a rise in pulmonary artery pressure, a fall in left atria1 pressure, tachycardia, and a fall in stroke volume without alteration in cardiac output. Some of the dogs were subsequently studied during pentobarbital anesthesia, and large increases in cardiac output were noted at mild levels of hypoxia but a decrease in output at a more severe level. It is concluded that marked differences occur in cardiac responses to hypoxia in the conscious versus the anethetized state and that the major hemodynamic alterations in conscious, resting dogs are tachycardia and a redistribution of blood flow.
Details
- Title: Subtitle
- Cardiovascular effects of low-oxygen atmospheres in conscious and anesthetized dogs
- Creators
- L D HorwitzV S BishopH L StoneH F Stegall
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1948), Vol.27(3), pp.370-373
- DOI
- 10.1152/jappl.1969.27.3.370
- PMID
- 5804135
- ISSN
- 0021-8987
- eISSN
- 2691-2473
- Language
- English
- Date published
- 09/1969
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656529202771
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