Journal article
Cardiovascular effects produced by systemic injections of nitro blue tetrazolium in the rat
European journal of pharmacology, Vol.241(1), pp.135-137
1993
DOI: 10.1016/0014-2999(93)90945-E
PMID: 8223921
Abstract
Nitro blue tetrazolium is a powerful electron acceptor which is widely used to localize NADPH-dependent flavin-containing enzymes known as NADPH diaphorases. By accepting electrons, nitro blue tetrazolium is known to inhibit the activity of these enzymes. The present study examined the effects of intravenous nitro blue tetrazolium on arterial blood pressure and regional blood flows in urethane-anesthetized rats. Nitro blue tetrazolium (0.1–5 mol/kg) produced a dose-dependent hypotension and differential effects on regional hemodynamics including decreases in hindquarter and mesenteric vascular resistances and a marked increase in renal resistance. These results demonstrate that systemic administration of nitro blue tetrazolium produces profound hemodynamic effects, the mechanisms of which remain to be elucidated.
Details
- Title: Subtitle
- Cardiovascular effects produced by systemic injections of nitro blue tetrazolium in the rat
- Creators
- Robin L Davisson - Department of Pharmacology and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, USATina M Walton - Department of Pharmacology and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, USAAlan Kim Johnson - Department of Psychology, The University of Iowa, Iowa City, IA 52242, USAStephen J Lewis - Department of Pharmacology and the Cardiovascular Center, The University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- European journal of pharmacology, Vol.241(1), pp.135-137
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0014-2999(93)90945-E
- PMID
- 8223921
- ISSN
- 0014-2999
- eISSN
- 1879-0712
- Language
- English
- Date published
- 1993
- Academic Unit
- Psychological and Brain Sciences; Neuroscience and Pharmacology; Health and Human Physiology
- Record Identifier
- 9984213408202771
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