Cardiovascular magnetic resonance characterization of left ventricular non-compaction provides independent prognostic information in patients with incident heart failure or suspected cardiomyopathy

Guha Ashrith; Dipti Gupta; Janel Hanmer; Robert M Weiss

doi:10.1186/s12968-014-0064-2

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Cardiovascular magnetic resonance characterization of left ventricular non-compaction provides independent prognostic information in patients with incident heart failure or suspected cardiomyopathy

Journal article

Open access

Peer reviewed

Cardiovascular magnetic resonance characterization of left ventricular non-compaction provides independent prognostic information in patients with incident heart failure or suspected cardiomyopathy

Guha Ashrith, Dipti Gupta, Janel Hanmer and Robert M Weiss

Journal of cardiovascular magnetic resonance, Vol.16(1), pp.64-64

10/02/2014

DOI: 10.1186/s12968-014-0064-2

PMCID: PMC4181715

PMID: 25285584

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Abstract

With recent advances in imaging methods, detection of LVNC is increasingly common. Concomitantly, the prognostic importance of LVNC is less clear. We followed 42 patients (63% male, age 44 ± 15 years) with incident heart failure or suspected cardiomyopathy, in whom cardiovascular magnetic resonance (CMR) yielded a diagnosis of LVNC, for 27 ± 16 months. LVNC was preferentially distributed among posterolateral segments, with apical predominance. Patients with maximum non-compacted-to-compacted thickness ratio (NC:C) < 3 improved by 0.9 ± 0.7 NYHA Class, compared to 0.3 ± 0.8 for patients with NC:C > 3 (p = 0.001). In 29 patients with baseline LVEF < 0.40, there was an inverse correlation between NC:C ratio, and the change in LVEF during follow-up. Tachyarrhythmias were observed in 42% of patients with LGE, and in 0% of patients without LGE (p = 0.02). In multivariate analysis, arrhythmia incidence was significantly higher in patients with LGE, even when adjusted for LVEF and RVEF. CMR assessments of myocardial morphology provide important prognostic information for patients with LVNC who present with incident heart failure or suspected cardiomyopathy.

Adult

Arrhythmias, Cardiac - diagnosis

Arrhythmias, Cardiac - epidemiology

Cardiomyopathies - diagnosis

Cardiomyopathies - epidemiology

Cardiomyopathies - pathology

Cardiomyopathies - physiopathology

Chi-Square Distribution

Female

Heart Failure - diagnosis

Heart Failure - epidemiology

Heart Failure - pathology

Heart Failure - physiopathology

Humans

Incidence

Iowa - epidemiology

Isolated Noncompaction of the Ventricular Myocardium - diagnosis

Isolated Noncompaction of the Ventricular Myocardium - epidemiology

Isolated Noncompaction of the Ventricular Myocardium - pathology

Logistic Models

Magnetic Resonance Imaging, Cine

Male

Middle Aged

Multivariate Analysis

Myocardium - pathology

Observer Variation

Predictive Value of Tests

Prognosis

Reproducibility of Results

Retrospective Studies

Risk Factors

Severity of Illness Index

Stroke Volume

Time Factors

Ventricular Function, Left

Ventricular Function, Right

Details

Title: Subtitle: Cardiovascular magnetic resonance characterization of left ventricular non-compaction provides independent prognostic information in patients with incident heart failure or suspected cardiomyopathy
Creators: Guha Ashrith - Houston Methodist
Dipti Gupta - Memorial Sloan Kettering Cancer Center
Janel Hanmer - University of Pittsburgh
Robert M Weiss - University of Iowa
Resource Type: Journal article
Publication Details: Journal of cardiovascular magnetic resonance, Vol.16(1), pp.64-64
DOI: 10.1186/s12968-014-0064-2
PMID: 25285584
PMCID: PMC4181715
NLM abbreviation: J Cardiovasc Magn Reson
ISSN: 1532-429X
eISSN: 1532-429X
Language: English
Date published: 10/02/2014
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984359814302771

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