Journal article
Cardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records
Nature communications, Vol.16(1), 3445
04/11/2025
DOI: 10.1038/s41467-025-56284-0
PMCID: PMC11992182
PMID: 40216777
Abstract
The risk of cardiovascular outcomes following SARS-CoV-2 infection has been reported in adults, but evidence in children and adolescents is limited. This paper assessed the risk of a multitude of cardiac signs, symptoms, and conditions 28-179 days after infection, with outcomes stratified by the presence of congenital heart defects (CHDs), using electronic health records (EHR) data from 19 children's hospitals and health institutions from the United States within the RECOVER consortium between March 2020 and September 2023. The cohort included 297,920 SARS-CoV-2-positive individuals and 915,402 SARS-CoV-2-negative controls. Every individual had at least a six-month follow-up after cohort entry. Here we show that children and adolescents with prior SARS-CoV-2 infection are at a statistically significant increased risk of various cardiovascular outcomes, including hypertension, ventricular arrhythmias, myocarditis, heart failure, cardiomyopathy, cardiac arrest, thromboembolism, chest pain, and palpitations, compared to uninfected controls. These findings were consistent among patients with and without CHDs. Awareness of the heightened risk of cardiovascular disorders after SARS-CoV-2 infection can lead to timely referrals, diagnostic evaluations, and management to mitigate long-term cardiovascular complications in children and adolescents.
Details
- Title: Subtitle
- Cardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records
- Creators
- Bingyu Zhang - University of PennsylvaniaDeepika Thacker - Nemours Children's Health SystemTing Zhou - University of PennsylvaniaDazheng Zhang - University of PennsylvaniaYuqing Lei - University of PennsylvaniaJiajie Chen - University of PennsylvaniaElizabeth A Chrischilles - University of IowaDimitri A Christakis - Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USASoledad Fernandez - The Ohio State UniversityVidu Garg - The Ohio State UniversitySusan Kim - University of California, San FranciscoAbu S M Mosa - University of MissouriMarion R Sills - Children's Hospital ColoradoBradley W Taylor - Medical College of WisconsinDavid A Williams - University of MichiganQiong Wu - University of PittsburghChristopher B Forrest - Children's Hospital of PhiladelphiaYong Chen - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.16(1), 3445
- DOI
- 10.1038/s41467-025-56284-0
- PMID
- 40216777
- PMCID
- PMC11992182
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- NATURE PORTFOLIO
- Grant note
- OT2HL161847-01 / U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)
- Language
- English
- Date published
- 04/11/2025
- Academic Unit
- Pharmacy; Epidemiology
- Record Identifier
- 9984808277402771
Metrics
6 Record Views